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Chemical Sampling Information |
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| Ethanolamine |
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General Description
Synonyms: 2-Aminoethanol; beta-Aminoethyl alcohol; Ethylolamine; 2-Hydroxyethylamine; Monoethanolamine
OSHA IMIS Code Number: 1030
Chemical Abstracts Service (CAS) Registry Number: 141-43-5
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KJ5775000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 2491 153
NIOSH Pocket Guide to Chemical Hazards, Ethanolamine: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 3 ppm, 6 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 3 ppm, 6 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 3 ppm, 6 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 3 ppm, 7.5 mg/m3 TWA; 6 ppm, 15 mg/m3 STEL
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 3 ppm, 8 mg/m3 TWA; 6 ppm, 15 mg/m3 STEL
Health Factors
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 30 ppm
Potential symptoms: Irritation of eyes, skin, respiratory system; drowsiness; cough, sore throat, shortness of breath; headache; eye redness, pain, burns; skin redness, pain, severe deep burns; INGES ACUTE: abdominal pain, burning sensation; shock or collapse
Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Cumulative liver, lung and kidney damage (HE3); Narcosis (HE8)
Affected organs: Eyes, skin, respiratory system, CNS
Notes:
- In a study with mice, radioactivity from topically applied radiolabeled ethanolamine was incorporated into skin and liver phosphatidylethanolamine, as well as into phosphatidylcholine and phosphatidylserine in liver. The amount of label exhaled as carbon dioxide exceeded the labeled urinary metabolites (choline, glycine, serine, urea and uric acid).
- A few cases of allergic contact dermatitis from exposure to ethanolamine in metalworking fluids have been reported.
- Ethanolamine is also a suspected cause of at least one case of asthma and a fatal case of acute respiratory distress syndrome.
Date Last Revised: 02/03/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Ethanolamine.
- International Chemical Safety Cards (WHO/IPCS/ILO): Ethanolamine.
- Bhushan, M., Craven, N.M. and Beck, M.H.: Contact allergy to 2-aminoethanol (monoethanolamine) in a soluble oil. Contact Dermatitis 39(6): 321, 1998.
- Geier, J., Lessmann, H., Schnuch, A. and Uter, W.: Contact sensitizations in metalworkers with occupational dermatitis exposed to water-based metalworking fluids: results of the research project “FaSt”. Int. Arch. Occup. Environ. Health 77(8): 543-551, 2004.
- Kamijo, Y., Soma, K., Inoue, A., Nagai, T. and Kurihara, K.: Acute respiratory distress syndrome following asthma-like symptoms from massive ingestion of a monoethanolamine-containing detergent. Vet. Hum. Toxicol. 46(2): 79-80, 2004.
- Klain, G.J., Reifenrath, W.G. and Black, K.E.: Distribution of topically applied ethanolamine. Fundam. Appl. Toxicol. 5(6 Pt. 2): S127-133, 1985.
- Pohanish, R.P. (editor): Ethanolamines. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1028-1031.
- Savonius, B., Keskinen, H., Tuppurainen, M. and Kanerva, L.: Occupational asthma caused by ethanolamines. Allergy 49(10): 877-881, 1994.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Coated XAD-2 Tube (80/40 sections, 20/60 mesh); coating is 10% (w/w) 1-Naphthylisothiocyanate (NITC)
analytical solvent: Dimethylformamide
maximum volume: 10 Liters maximum flow rate: 0.1 L/min (TWA)
maximum volume: 1.5 Liters maximum flow rate: 0.1 L/min (STEL)
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: OSHA Analytical Method (OSHA PV2111)
method classification: Partially Validated
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