Framingham Heart Study Offspring
Objectives:
The objectives of the Framingham Offspring Study are
to study the incidence and prevalence of cardiovascular disease (CVD) and its
risk factors, trends in CVD incidence and its risk factors over time, family
patterns of CVD and risk factors. Less prominent but important objectives
include the estimation of incidence rates of disease and description of the
natural history of cardiovascular disease, including the sequence of clinical
signs and systems that precede the clinically recognizable syndrome, and the
consequences and course of clinically manifest disease.
Background:
With the aging of the Framingham cohort and with
interest in familiar aggregation and heritability, a new cohort consisting of
the offspring of the original cohort was sampled. Spouses of offspring were
also included. This new sample, begun in 1971, constituted a second generation
of participants, permitted new assessment of risk factors and outcomes, and
provided a resource for the genetic analyses which were yet to come. The
Offspring participants have had repeated examinations, though at longer
intervals than the cohort.
Subjects:
5,124 men and women, ages 5-70 years at entry
consisting of offspring of the original Framingham cohort (and spouses of the
offspring) participated in the study.
Design:
By 1975, a sample of 5,124 men and women, consisting
of offspring of the original Framingham cohort (and spouses of the offspring)
had participated in the study. Additional studies of these subjects continued
under research contracts. Participants have completed six examinations with
intervals of four to six years and have been followed for morbidity and
mortality over that time period.
The cardiovascular disease conditions under
investigation include coronary heart disease (angina pectoris, myocardial
infarction, coronary insufficiency and sudden and non-sudden death), stroke,
hypertension, peripheral arterial disease and congestive heart failure.
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Study Website |
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Study Documentation |
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Data Distribution Agreement |
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