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Sponsored by: |
Hospital de Clinicas de Porto Alegre |
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Information provided by: | Hospital de Clinicas de Porto Alegre |
ClinicalTrials.gov Identifier: | NCT00394394 |
The majority of hypertensive patients require antihypertensive associations to control their blood pressure. Most of clinical trials don’t compare different associations using Hydrochlorothiazide 25 mg as the standard initial therapy and compare the associations using doses that are not equivalent.
This randomized trial where patients and investigators are blinded and compares the effectiveness two associations: Hydrochlorothiazide and Amiloride and Hydrochlorothiazide and Enalapril.
Condition | Intervention | Phase |
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Hypertension |
Drug: Amiloride 2,5/d or Enalapril/d 10 mg |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Hydrochlorothiazide and Amiloride vs Hydrochlorothiazide and Enalapril: a Randomized Clinical Trial of Antihypertensive Effectiveness. |
Study Start Date: | February 2005 |
Ages Eligible for Study: | 18 Years to 75 Years |
Genders Eligible for Study: | Both |
Inclusion Criteria:
Exclusion Criteria:
Brazil, Rio Grande do Sul | |
Hospital de Clínicas de Porto Alegre | |
Porto Alegre, Rio Grande do Sul, Brazil, 90035-903 |
Principal Investigator: | Miguel Gus | Hospital de Clínicas de Porto Alegre |
Study ID Numbers: | 04002 |
Study First Received: | October 30, 2006 |
Last Updated: | October 30, 2006 |
ClinicalTrials.gov Identifier: | NCT00394394 History of Changes |
Health Authority: | Brazil: National Committee of Ethics in Research |
Enalapril Enalaprilat Sodium Chloride Symporter Inhibitors Diuretics Amiloride Vascular Diseases |
Angiotensin-Converting Enzyme Inhibitors Cardiovascular Agents Antihypertensive Agents Hydrochlorothiazide Protease Inhibitors Hypertension |
Molecular Mechanisms of Pharmacological Action Sodium Chloride Symporter Inhibitors Physiological Effects of Drugs Diuretics Vascular Diseases Amiloride Enzyme Inhibitors Cardiovascular Agents Antihypertensive Agents Hydrochlorothiazide Pharmacologic Actions |
Protease Inhibitors Membrane Transport Modulators Enalapril Enalaprilat Natriuretic Agents Therapeutic Uses Angiotensin-Converting Enzyme Inhibitors Cardiovascular Diseases Sodium Channel Blockers Hypertension |