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Sponsored by: |
Johann Wolfgang Goethe University Hospitals |
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Information provided by: | Johann Wolfgang Goethe University Hospitals |
ClinicalTrials.gov Identifier: | NCT00289822 |
Impaired contractile function after a heart attack and due to coronary heart disease is a major cause of "heart failure" limiting quality of life and prognosis, which cannot be prevented even with optimal standard therapy.
The aim of the current trial is to investigate whether infusion of progenitor cells into the coronary artery supplying the most dyskinetic left ventricular area may improve left ventricular contractile function, compared to no cell infusion in the control group, in patients with old (>= 3 months) myocardial infarction.
Condition | Intervention | Phase |
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Coronary Artery Disease |
Drug: intracoronary infusion of progenitor cells |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Open Label, Active Control, Crossover Assignment, Safety/Efficacy Study |
Official Title: | Cell Therapy for Coronary Heart Disease: Infusion of Autologous Ex Vivo Cultivated Endothelial Progenitor Cells (EPCs)” and Autologous Bone Marrow Progenitor Cells in Crossover Design for Improvement of Vascularization and Cardiac Function |
Estimated Enrollment: | 75 |
Study Start Date: | January 2002 |
Estimated Study Completion Date: | January 2005 |
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Existing neoplastic disease or signs of tumor recurrence within the last 5 years
Germany | |
J. W. Goethe University Hospitals | |
Frankfurt, Germany, 60590 |
Principal Investigator: | Andreas M Zeiher, MD | J. W. Goethe University Hospitals |
Study Director: | Volker Schaechinger, MD | J. W. Goethe University Hospitals |
Study ID Numbers: | 158/02 |
Study First Received: | February 8, 2006 |
Last Updated: | November 29, 2006 |
ClinicalTrials.gov Identifier: | NCT00289822 History of Changes |
Health Authority: | Germany: Paul-Ehrlich-Institut |
chronic heart failure myocardial infarction |
Arterial Occlusive Diseases Coronary Disease Heart Failure Heart Diseases Myocardial Ischemia Vascular Diseases |
Arteriosclerosis Ischemia Neovascularization, Pathologic Infarction Myocardial Infarction Coronary Artery Disease |
Arterial Occlusive Diseases Coronary Disease Heart Diseases Myocardial Ischemia |
Vascular Diseases Cardiovascular Diseases Arteriosclerosis Coronary Artery Disease |