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Changes in Different Fat Compartments and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures.
This study is currently recruiting participants.
Verified by Hadassah Medical Organization, January 2007
First Received: February 5, 2007   Last Updated: April 16, 2008   History of Changes
Sponsored by: Hadassah Medical Organization
Information provided by: Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT00431587
  Purpose

The metabolic risks associated with obesity are closely correlated with central (abdominal), rather than a peripheral (gluteofemoral) fat pattern It has been shown that weight loss after bariatric surgery is followed by metabolic improvements.

The amount of fat lost from each site may be independently regulated. Very scant information is found in the literature regarding the relative changes in different fat body compartments, and their effect on the improvement of the metabolic profile. In this study we define the absolute and relative changes in the different adipose tissue compartment after weight loss surgery


Condition
Morbid Obesity
Metabolic Syndrome
Visceral Obesity

MedlinePlus related topics: Obesity Weight Control
U.S. FDA Resources
Study Type: Observational
Study Design: Prospective
Official Title: Changes in Different Fat Compartments During Weight Loss and Their Effect on Particular Manifestations of Metabolic Syndrome After Bariatric Procedures.

Further study details as provided by Hadassah Medical Organization:

Estimated Enrollment: 1000
Study Start Date: June 2007
Detailed Description:

The metabolic risks associated with obesity are closely correlated with central (abdominal), rather than a peripheral (gluteofemoral) fat pattern.

The amount of fat lost from each site may be independently regulated. Very scant information is found in the literature regarding the relative changes in different fat body compartments.

Rapid and preferential reduction of visceral fat mass could occur in morbid obese with visceral obesity. It has been previously shown, and it was also partially confirmed in this study, that a reduction in visceral fat was associated with metabolic improvements that included improved glucose tolerance and reduced plasma insulin and lipid levels. This again suggests a threshold of proportional visceral fat loss, above which there is an improvement in insulin sensitivity and other component of metabolic syndrom. We will quantify the different fat compartments changes after bariatric surgery by means of CT scan.

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Morbid obesity,
  • Metabolic syndrome

Exclusion Criteria:

  • Previous abdominoplasty surgery,
  • Previous major abdominal surgey
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00431587

Contacts
Contact: Andrei Keidar, MD 00 972 2 6777384 andreik@hadassah.org.il

Locations
Israel
Hadassah Medical Organization, Recruiting
Jerusalem, Israel
Contact: Arik Tzukert, DMD     00 972 2 6776095     arik@hadassah.org.il    
Contact: Hadas Lemberg, PhD     00 972 2 6777572        
Sponsors and Collaborators
Hadassah Medical Organization
Investigators
Principal Investigator: Andrei Keidar, MD Hadassah Medical Organization
  More Information

No publications provided

Study ID Numbers: metabo-HMO-CTIL
Study First Received: February 5, 2007
Last Updated: April 16, 2008
ClinicalTrials.gov Identifier: NCT00431587     History of Changes
Health Authority: Israel: Israeli Health Ministry Pharmaceutical Administration

Keywords provided by Hadassah Medical Organization:
morbid obesity
metabolic syndrome
visceral fat
peripheral fat

Study placed in the following topic categories:
Body Weight
Signs and Symptoms
Obesity
Weight Loss
Nutrition Disorders
Overweight
Overnutrition
Obesity, Morbid

Additional relevant MeSH terms:
Body Weight
Signs and Symptoms
Obesity
Pathologic Processes
Disease
Syndrome
Nutrition Disorders
Overweight
Overnutrition
Obesity, Morbid

ClinicalTrials.gov processed this record on May 07, 2009