Effectiveness of Transference-Focused Psychotherapy for Borderline Personality Disorder - Full Text View

Sponsored by:	University Hospital Muenster
Information provided by:	University Hospital Muenster
ClinicalTrials.gov Identifier:	NCT00714311

Purpose

The purpose of this study is to find out whether Transference-Focused Psychotherapy (TFP) is effective in the treatment of Borderline Personality Disorder.

Condition	Intervention
Borderline Personality Disorder	Behavioral: Transference-Focused Psychotherapy Behavioral: Treatment as usual

MedlinePlus related topics: Personality Disorders

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Single Blind (Outcomes Assessor), Active Control, Parallel Assignment, Efficacy Study
Official Title:	A Randomized-Controlled Trial of Transference-Focused Psychotherapy vs. Treatment as Usual for Borderline Personality Disorder

Further study details as provided by University Hospital Muenster:

Primary Outcome Measures:

Drop-out [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Suicidality (suicide attempts) [ Time Frame: 1 year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Psychosocial Functioning (Global Assessment of Functioning, GAF-Score) [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Level of personality organization (Structured Interview for Personality Organization, STIPO) [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Number of self-harming acts [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Self-assessment of psychopathology (BDI, STAI, BSI) [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Attachment style and Reflective Function (Adult Attachment Interview, AAI) [ Time Frame: 1 year ] [ Designated as safety issue: No ]
Borderline symptomatology (DSM-IV criteria) [ Time Frame: 1 month ] [ Designated as safety issue: No ]

Estimated Enrollment:	104
Study Start Date:	October 2004
Estimated Study Completion Date:	February 2012
Primary Completion Date:	February 2008 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
TFP: Active Comparator Transference-Focused Psychotherapy	Behavioral: Transference-Focused Psychotherapy Outpatient psychotherapy according to the treatment manual, sessions of 50 minutes twice per week
TAU: Active Comparator Treatment as usual	Behavioral: Treatment as usual Outpatient psychotherapy in private practices or outpatient units of psychiatric hospitals. Licensed psychotherapists are treating according to the method they have learned.

Detailed Description:

Borderline personality disorder represents a sever clinical condition that affects 1-2% of the community and is characterized by a pervasive instability of interpersonal relationships, self-image, and affects, as well as a marked impulsivity; up to 10% of the patients commit suicide.

Transference-Focused Psychotherapy (TFP) is one psychotherapeutic approach among five that have been manualized and evaluated in RCTs. So far, TFP has not been compared to treatment as usual which is a crucial step in the evaluation of the effectiveness of a psychosocial intervention.

This study is an RCT that compares one year of outpatient TFP to treatment as usual for borderline personality disorder.

Eligibility

Ages Eligible for Study:	18 Years to 45 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Written informed consent to the participation in the study
Diagnosis of BPD according to DSM-IV as assessed using the SCID-II
Age between 18 and 45 years
Sufficient knowledge of the German language

Exclusion Criteria:

Diagnosis of schizophrenia, bipolar disorder, severe substance abuse, organic pathology, or mental retardation according to DSM-IV as assessed using the SCID-I
Diagnosis of antisocial personality disorder according to DSM-IV as assessed using the SCID-II

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00714311

Contacts

Contact: Stephan Doering, MD	+49-251-83 ext 47074	stephan.doering@ukmuenster.de
Contact: Peter Buchheim, MD	+49-15150402763	P.Buchheim@lrz.tu-muenchen.de

Locations

Austria
Dept. of Psychoanalysis and Psychotherapy, Medical University Vienna	Recruiting
Vienna, Austria, 1090
Contact: Melitta Fischer-Kern, MD +43-1-40400 ext 3069 melitta.fischer-kern@meduniwien.ac.at
Contact: Peter Schuster, MD +43-1-40400 ext 3073 peter.schuster@meduniwien.ac.at
Principal Investigator: Peter Schuster, MD
Sub-Investigator: Melitta Fischer-Kern, MD
Germany, Bavaria
Dept. of Psychiatry, Technical University of Munich	Recruiting
Munich, Bavaria, Germany, 81675
Contact: Michael Rentrop, MD +49-89-4140 ext 4265 michael.rentrop@lrz.tu-muenchen.de
Contact: Susanne Hoerz, PhD +49-89-4140 ext 4142 hoerz@gmx.net
Principal Investigator: Michael Rentrop, MD
Sub-Investigator: Susanne Hoerz, PhD

Sponsors and Collaborators

University Hospital Muenster

Investigators

Principal Investigator:

Stephan Doering, MD

University of Muenster, Germany

More Information

Publications:

Clarkin JF, Levy KN, Lenzenweger MF, Kernberg OF. Evaluating three treatments for borderline personality disorder: a multiwave study. Am J Psychiatry. 2007 Jun;164(6):922-8.

Levy KN, Meehan KB, Kelly KM, Reynoso JS, Weber M, Clarkin JF, Kernberg OF. Change in attachment patterns and reflective function in a randomized control trial of transference-focused psychotherapy for borderline personality disorder. J Consult Clin Psychol. 2006 Dec;74(6):1027-40.

Kernberg OF, Yeomans FE, Clarkin JF, Levy KN. Transference focused psychotherapy: Overview and update. Int J Psychoanal. 2008 Jun;89(3):601-20.

Responsible Party:	University of Muenster, Germany ( Stephan Doering, MD )
Study ID Numbers:	1106/04, 10636, DPG0802
Study First Received:	July 9, 2008
Last Updated:	July 15, 2008
ClinicalTrials.gov Identifier:	NCT00714311
Health Authority:	Germany: Ethics Commission

Keywords provided by University Hospital Muenster:

borderline personality disorder
randomized controlled trial
Transference-Focused Psychotherapy
treatment as usual

Study placed in the following topic categories:

Mental Disorders
Borderline Personality Disorder
Personality Disorders

Additional relevant MeSH terms:

Pathologic Processes
Disease

ClinicalTrials.gov processed this record on January 16, 2009