Home
Search
Study Topics
Glossary
|
|
|
|
|
Sponsors and Collaborators: |
University of Alberta, Graduate Orthodontic Program University of Alberta |
---|---|
Information provided by: | University of Alberta, Graduate Orthodontic Program |
ClinicalTrials.gov Identifier: | NCT00471393 |
The use of a topical medication was compared to placebo to be applied over the symptomatic temporomandibular joint in women with the diagnosis of osteoarthritis of the temporomandibular joint(s).
The hypothesis is to investigate whether the use of a topical anti-inflammatory medication when compared to the placebo would decrease the pain of the affected joint and/or increased mouth opening.
Condition | Intervention |
---|---|
Temporomandibular Degenerative Joint Disease. |
Drug: 1.5% diclofenac in 45.5% DMSO (topical treatment) Drug: 45.5% DMSO (topical placebo) |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | Double-Blind Randomized Clinical Study on Topical Diclofenac Efficacy in Symptomatic Relief of Temporomandibular Degenerative Joint Disease in Women. |
Enrollment: | 28 |
Study Start Date: | May 2006 |
Study Completion Date: | April 2007 |
The purpose of this study is to measure the efficacy of topical diclofenac to topical placebo in the symptomatic relief of degenerative temporomandibular joint disease in a female population between the ages of 18-45 years of age.
Primary Objectives:
Secondary Objectives:
Tertiary Objectives
The null hypothesis is that there is no difference between the efficacy of topical diclofenac and topical placebo in the treatment of degenerative temporomandibular joint disease.
Ages Eligible for Study: | 18 Years to 45 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Canada, Alberta | |
University of Alberta | |
Edmonton, Alberta, Canada, T6G 2N8 |
Study Director: | Norman Thie, BSc DDS MSc | University of Alberta |
Study ID Numbers: | FMW 5936, File #103090 Health Canada, Grant#2005-04 |
Study First Received: | May 7, 2007 |
Last Updated: | May 7, 2007 |
ClinicalTrials.gov Identifier: | NCT00471393 History of Changes |
Health Authority: | Canada: Health Canada |
TMJ Osteoarthritis Degenerative Joint disease |
Anti-Inflammatory Agents Osteoarthritis Joint Diseases Cyclooxygenase Inhibitors Diclofenac Rheumatic Diseases Musculoskeletal Diseases |
Analgesics, Non-Narcotic Arthritis Anti-Inflammatory Agents, Non-Steroidal Analgesics Peripheral Nervous System Agents Antirheumatic Agents |
Anti-Inflammatory Agents Molecular Mechanisms of Pharmacological Action Osteoarthritis Joint Diseases Cyclooxygenase Inhibitors Physiological Effects of Drugs Diclofenac Enzyme Inhibitors Rheumatic Diseases Pharmacologic Actions |
Musculoskeletal Diseases Analgesics, Non-Narcotic Sensory System Agents Therapeutic Uses Arthritis Anti-Inflammatory Agents, Non-Steroidal Analgesics Peripheral Nervous System Agents Antirheumatic Agents Central Nervous System Agents |