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Sponsored by: |
National Institute of Mental Health (NIMH) |
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Information provided by: | National Institute of Mental Health (NIMH) |
ClinicalTrials.gov Identifier: | NCT00071604 |
This study will determine whether Medication Adherence Therapy (MAT) can improve medication adherence and lower the risk of rehospitalization in older patients with psychosis.
Condition | Intervention |
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Psychotic Disorders Schizophrenia |
Behavioral: Medication Adherence Therapy Behavioral: Friendly Support Group |
Study Type: | Interventional |
Study Design: | Randomized, Double-Blind, Active Control, Parallel Assignment, Efficacy Study |
Official Title: | Medication Adherence in Older Psychotic People |
Estimated Enrollment: | 240 |
Study Start Date: | September 2002 |
Estimated Study Completion Date: | May 2008 |
Psychoses are among the most common and serious psychiatric disorders. Currently, the most effective treatment for psychoses involves the use of antipsychotic or neuroleptic medications. Unfortunately, pharmacologic regimens often do not achieve their goals because of poor medication adherence.
Nonadherence to antipsychotic treatment is a considerable public health problem that leads to myriad clinical and economic burdens, including psychotic relapse, increased clinic and emergency room visits, and rehospitalization.
Participants in this study are randomly assigned to receive either MAT or supportive treatment for 12 weeks. MAT is given in 15 sessions and consists of motivational interviewing, education, and social skills and behavior modification. Individual MAT sessions are held in Weeks 1 and 12; small group sessions take place in Weeks 2 through 11. Three monthly booster group sessions begin in Week 16. Participants are assessed at baseline and at 3, 6, and 12 months. Medication adherence, psychopathology, quality of life, medication side effects, health beliefs, and functioning are assessed.
Ages Eligible for Study: | 40 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
United States, California | |
Division of Geriatric Psychiatry Center (University of California, San Diego) | |
San Diego, California, United States, 92161 |
Principal Investigator: | Jonathan Lacro, PharmD | VA San Diego Healthcare System & University of California, San Diego |
Study ID Numbers: | R01 MH62849, DATR A4-GPS |
Study First Received: | October 29, 2003 |
Last Updated: | April 24, 2008 |
ClinicalTrials.gov Identifier: | NCT00071604 History of Changes |
Health Authority: | United States: Federal Government |
Schizophrenia Mental Disorders Psychotic Disorders Schizophrenia and Disorders with Psychotic Features |
Schizophrenia Mental Disorders Psychotic Disorders Schizophrenia and Disorders with Psychotic Features |