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Sponsors and Collaborators: |
Columbia University National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institute of Neurological Disorders and Stroke (NINDS) |
ClinicalTrials.gov Identifier: | NCT00104585 |
The purpose of this study is to investigate genetic and environmental risk factors that increase susceptibility to the development of early-onset Parkinson's disease (developed at or before age 50).
Condition |
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Parkinson's Disease |
Study Type: | Observational |
Study Design: | Family-Based, Cross-Sectional |
Official Title: | Genetic Epidemiology of Parkinson's Disease |
whole blood
Estimated Enrollment: | 800 |
Study Start Date: | July 2004 |
Estimated Study Completion Date: | April 2009 |
Estimated Primary Completion Date: | April 2009 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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People with young onset Parkinson's disease and their family members
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Parkinson's disease (PD) is a common, neurodegenerative condition. Although mostly a late-onset disorder, 10 percent of people with PD are reported to develop symptoms before the age of 50. To date, six genes have been found to be associated with PD, however the majority have been found in rare PD 'families'. Some studies have also identified a number of environmental risk factors, such as pesticide use, that appear to increase the risk of PD.
In a previous study, Dr. Karen Marder and her research team found that close family members of people with both early- and late-onset PD have a three-fold increased risk of PD compared to close family members of people without PD.
The purpose of the Consortium On Risk for Early-onset Parkinson's Disease (CORE PD) study is to identify the genetic factors that contribute to the development of early-onset Parkinson's disease, and to understand how these genetic factors interact with other genes and the environment to cause PD.
Participation in the study involves a blood draw (to look for genetic factors associated with PD), questionnaires collecting information on family and medical history, and a neurological examination. In addition participants may be contacted in the future and asked to participate in a more detailed interview. At that time, study investigators will also ask participants for permission to contact family members to invite them to participate in the study.
This research study requires participants to sign a consent form, which states that the research is voluntary and confidential. In addition, since this is a research study, genetic results are not released to participants or their family members now or in the future.
Scientists hope this multi-center study will increase the current knowledge of PD and that the identification of factors that cause PD will lead to better diagnosis and treatment.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Young onset PD patients
Inclusion Criteria:
Contact: Helen Mejia-Santana, M.A. | 877-305-2438 | research@corepdstudy.org |
United States, California | |
The Parkinson's Institute | Recruiting |
Sunnyvale, California, United States, 94089 | |
Contact: Kathleen Comyns 408-542-5620 kcomyns@parkinsonsinstitute.org | |
United States, Connecticut | |
The Institute for Neurodegenerative Disorders | Recruiting |
New Haven, Connecticut, United States, 06510 | |
Contact: Debbie Ruotolo 203-401-4366 druotolo@mnimaging.com | |
United States, Illinois | |
Rush University Medical Center | Recruiting |
Chicago, Illinois, United States, 60612 | |
Contact: Lucia M. Blasucci 312-563-2900 Lucia_M_Blasucci@rush.edu | |
Glenbrook Hospital, Evanston | Recruiting |
Glenview, Illinois, United States, 60026 | |
Contact: Susan Silvio 847-657-5689 ssilvio@enh.org | |
United States, Maryland | |
Johns Hopkins Hospital | Recruiting |
Baltimore, Maryland, United States, 21287 | |
Contact: Melissa Gerstenhaber 410-614-1242 mgerste1@jhmi.edu | |
United States, Minnesota | |
Struthers Parkinson's Center | Recruiting |
Golden Valley, Minnesota, United States, 55427 | |
Contact: Patricia Ede 952-993-2245 patriciaede@parknicollet.com | |
United States, New York | |
Columbia University | Recruiting |
New York, New York, United States, 10032 | |
Contact: Helen Mejia-Santana 877-305-2438 research@corepdstudy.org | |
Beth Israel Medical Center | Recruiting |
New York, New York, United States, 10003 | |
Contact: Paul Soto 212-844-6053 | |
United States, Pennsylvania | |
University of Pennsylvania | Recruiting |
Philadelphia, Pennsylvania, United States, 19104 | |
Contact: Dana Clay 215-829-7731 cdana@mail.med.upenn.edu | |
United States, Rhode Island | |
Neuro Health | Recruiting |
Warwick, Rhode Island, United States, 02886 | |
Contact: Meg Lannon 401-921-4245 mclannon@neurohealth.info | |
United States, Tennessee | |
University of Tennessee Health Science Center | Recruiting |
Memphis, Tennessee, United States, 38136 | |
Contact: Brenda Pfeiffer 901-271-5966 bpfeiffer@utmem.edu | |
United States, Wisconsin | |
Marshfield Clinic | Recruiting |
Marshfield, Wisconsin, United States, 54449 | |
Contact: Pam Mundt 715-387-5544 mundt.pamela@mcrf.mfldclin.edu |
Principal Investigator: | Karen Marder, M.D., M.PH. | Columbia University |
Responsible Party: | Columbia University ( Karen Marder, MD, MPH, Sally Kerlin Professor of Neurology ) |
Study ID Numbers: | R01NS036630 |
Study First Received: | March 1, 2005 |
Last Updated: | March 31, 2009 |
ClinicalTrials.gov Identifier: | NCT00104585 History of Changes |
Health Authority: | United States: Federal Government |
Parkinson's disease PD gene environment early-onset Parkinson's disease |
Ganglion Cysts Movement Disorders Parkinson Disease Basal Ganglia Diseases |
Central Nervous System Diseases Parkinsonian Disorders Neurodegenerative Diseases Brain Diseases |
Movement Disorders Parkinson Disease Nervous System Diseases Basal Ganglia Diseases |
Central Nervous System Diseases Parkinsonian Disorders Neurodegenerative Diseases Brain Diseases |