Inclusion Criteria:

1. Men, at least 18 years of age, willing to participate in the study and willing to regularly attempt sexual activity.
2. Patients with histologically proven prostate cancer.
3. Provide signed informed consent.
4. Patients with normal erectile function defined as a combined score >=8 of questions 3 and 4 of the IIEF.
5. Agree not to use any other ED treatment during the study.

Exclusion Criteria:

1. Use of any treatment for ED before the start of the study.
2. History of pelvic surgery (including radical prostatectomy)
3. History of penile implant
4. The presence of penile deformity that makes sexual intercourse difficult or impossible.
5. Patients with chronic stable angina treated with long-acting nitrates, or patients with chronic stable angina who have required short-acting nitrates in the last 90 days, or angina occurring during sexual intercourse in the last 6 months.
6. Patients with unstable angina, history of myocardial infarction or coronary artery bypass graft surgery or percutaneous coronary intervention (eg, angioplasty or stent placement) within 90 days before screening.
7. Any supraventricular arrhythmia with an uncontrolled ventricular response (mean heart rate >100 bpm) at rest despite medical or device therapy, or any history of spontaneous or induced sustained ventricular tachycardia (heart rate >100 bpm for 30 sec) despite medical or device therapy, or the presence of an automatic internal cardioverter-defibrillator.
8. A history of sudden cardiac arrest despite medical or device therapy.
9. Any evidence of congestive heart failure or a new, significant conduction defect within 90 days before screening.
10. Systolic blood pressure >170 or <90 mm Hg or diastolic blood pressure >100 or <50 mm Hg, or patients with a history of malignant hypertension.
11. History of significant central nervous system injuries (including stroke and spinal cord injury) within the 6 months before screening.
12. History of HIV infection.
13. Any condition that would interfere with the patient’s ability to provide informed consent or comply with study instructions, would place patient at increased risk, or might confound the interpretation of the study results.
14. Treatment with cancer chemotherapy.
15. History of drug, alcohol, or substance abuse within the 6 months before screening.
16. Have any condition, limitation, or disease that could, in the judgment of the investigator, preclude evaluation of response to tadalafil.