Ghrelin Levels in Early IVF Pregnancies

This study has been completed.

First Received: May 3, 2007 Last Updated: May 4, 2007 History of Changes

Sponsored by:	Instituto Valenciano de Infertilidad, Spain
Information provided by:	Instituto Valenciano de Infertilidad, Spain
ClinicalTrials.gov Identifier:	NCT00469807

Purpose

In this study, we have assessed the potential prognostic value for gestational outcome of maternal ghrelin levels at very early stages of IVF pregnancies. In addition, ghrelin responses to meal intake were explored at early gestation.

Condition
Pregnancy

Drug Information available for: Ghrelin

U.S. FDA Resources

Study Type:	Observational
Study Design:	Longitudinal, Convenience Sample, Prospective Study
Official Title:	Maternal Serum Ghrelin Levels in Early IVF Pregnancies: Lack of Prognostic Value for Gestational Outcome and Altered Post-Prandial Responses

Further study details as provided by Instituto Valenciano de Infertilidad, Spain:

Study Start Date:	June 2004
Study Completion Date:	May 2007

Detailed Description:

Ghrelin is a pleiotropic hormone recently involved in the control of growthand metabolism, whose circulating levels fluctuate in relation to food intake and body mass index. Ghrelin has been detected in the decidualized endometrium, as well as in human and rat placenta, with a distinctive temporal pattern of expression along pregnancy. Comparison(s): A total of 106 patients undergoing IVF procedures were prospectively recruited. On d-16 and 23 after oocyte retrieval, the patients were subjected to blood sampling after overnight fasting, for determination of serum ghrelin, hCG and progesterone levels. In addition, ghrelin levels were assayed in these groups, 2-h after ingestion of a fixed-calorie meal.

Eligibility

Ages Eligible for Study:	18 Years to 50 Years
Genders Eligible for Study:	Female
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria: - Patients undergoing IVF

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00469807

Locations

Spain
Ivi Valencia
Valencia, Spain, 46015

Sponsors and Collaborators

Instituto Valenciano de Infertilidad, Spain

Investigators

Study Chair:

Antonio Pellicer, MD

Instituto Valenciano de Infertilidad

More Information

No publications provided

Study ID Numbers:	VLC-CV-0604-507-22
Study First Received:	May 3, 2007
Last Updated:	May 4, 2007
ClinicalTrials.gov Identifier:	NCT00469807 History of Changes
Health Authority:	Spain: Comité Ético de Investigación Clínica

Keywords provided by Instituto Valenciano de Infertilidad, Spain:

Ghrelin
Pregnancy outcome

ClinicalTrials.gov processed this record on May 06, 2009