Ambient Air Pollution, Preeclampsia, and Preterm Delivery

This study is ongoing, but not recruiting participants.

First Received: May 2, 2007 No Changes Posted

Sponsored by:	National Institute of Environmental Health Sciences (NIEHS)
Information provided by:	National Institute of Environmental Health Sciences (NIEHS)
ClinicalTrials.gov Identifier:	NCT00468663

Purpose

An epidemiologic study of pregnant women in western Washington to measure the relationships between exposure to air pollutants and risks of preeclampsia and preterm delivery.

Condition
Preeclampsia Preterm Delivery

MedlinePlus related topics: Air Pollution

U.S. FDA Resources

Study Type:	Observational
Study Design:	Natural History, Longitudinal, Defined Population, Prospective Study
Official Title:	Ambient Air Pollution, Preeclampsia, and Preterm Delivery

Further study details as provided by National Institute of Environmental Health Sciences (NIEHS):

Enrollment:	4200
Study Start Date:	July 2006

Detailed Description:

We will design models that use local traffic, weather, and population characteristics to predict monthly ambient concentrations of fine particulate matter (PM2.5) and carbon monoxide (CO). These models will be used to estimate study participants' PM2.5 and CO exposures during and before pregnancy.

We will test whether these air pollutant exposures are associated with subsequent risk of preeclampsia and preterm delivery. Additionally, we will test biological markers of maternal lipid peroxidation (thiobarbituric acid reactive substances) and inflammation (high sensitivity C-reactive protein) in maternal blood samples drawn during early pregnancy. We will also examine carboxyhemoglobin measured in early-pregnancy maternal blood samples as a marker of CO exposure.

Eligibility

Ages Eligible for Study:

18 Years and older

Criteria

Inclusion Criteria:

English speaking
enrolled in parent study
pregnant at <20 weeks gestation and attending prenatal care clinics affiliated with Swedish Medical Center and Tacoma General Hospital

Exclusion Criteria:

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00468663

Sponsors and Collaborators

National Institute of Environmental Health Sciences (NIEHS)

Investigators

Principal Investigator:	Carole Rudra, Ph.D, MPH	Swedish Medical Center, First Hill
Principal Investigator:	Michelle A Williams, Sc.D	Swedish Medical Center

More Information

No publications provided

Study ID Numbers:	14716-CP-001
Study First Received:	May 2, 2007
Last Updated:	May 2, 2007
ClinicalTrials.gov Identifier:	NCT00468663 History of Changes
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Environmental Health Sciences (NIEHS):

preeclampsia
preterm delivery
lipid peroxidation
inflammation

Study placed in the following topic categories:

Hypertension, Pregnancy-Induced
Pregnancy Complications
Eclampsia
Obstetric Labor, Premature
Obstetric Labor Complications

Pre-Eclampsia
Preeclampsia
Hypertension
Inflammation
Premature Birth

Additional relevant MeSH terms:

Hypertension, Pregnancy-Induced
Pregnancy Complications
Obstetric Labor, Premature

Obstetric Labor Complications
Pre-Eclampsia
Premature Birth

ClinicalTrials.gov processed this record on May 06, 2009