Inclusion Criteria:

1. Men or women > 18 years of age;
2. Has signed and dated the most recent informed consent form approved by an IRB;
3. Will, in the opinion of the PI, be compliant with prescribed phosphate binder therapy;
4. Must be able to communicate with the investigator, and be able to understand and comply with the requirements of the study;
5. Has a life expectancy >12 months;
6. An eGFR rate (estimated by the MDRD equation) ≥ 20 and ≤ 45 mL/min/1.73m2 obtained by screening laboratory values and in the opinion of the investigator felt to have CKD without evidence of recent acute kidney injury or unexpected decline in renal function;
7. Two phosphorus measures in the range of > 3.5 mg/dL and ≤ 6.0 mg/dL during screening;
8. Must consume a minimum of 2 meals per day and be willing to avoid intentional changes in diet;
9. Women of child bearing potential must be practicing an acceptable form of birth control.

Exclusion Criteria:

1. Receiving or has received an investigational drug (or is currently using an investigational device) within 30 days prior to baseline;
2. An episode of acute kidney injury in the last 90 days;
3. Subject is pregnant, is breast feeding or is of child bearing potential and not using acceptable birth control measures;
4. Exceeds the weight of the EBCT scanner (> 350 lbs.);
5. Active atrial fibrillation or atrial flutter;
6. Has known primary hyperparathyroidism;
7. Has had a previous renal transplant;
8. Has a chronic reliance on enemas or laxatives;
9. Has a known sensitivity or previous intolerance to any of the products to be administered during the study;
10. Clinical evidence of active malignancy and/or receiving systemic chemotherapy/radiotherapy with the exception of basal cell or squamous carcinoma of the skin;
11. Currently has an active infection or is being treated with antibiotics (within 14 days prior to screening);
12. Has been hospitalized within 30 days prior to baseline (with the exception of hospitalizations due to vascular access procedures);
13. Any surgical or medical condition which might significantly alter the function of phosphorus binders or which may jeopardize the subject in case of participation in the study. The investigator should be guided by evidence of any of the following: Severe gastrointestinal motility disorder,Bowel obstruction,Dysphagia or other disorders of swallowing, Acute peptic ulcer, Ulcerative colitis or Crohn's disease, History of major gastrointestinal tract surgery, Severe malabsorption;
14. Currently taking any of the following within 30 days prior to baseline; Calcitriol or its analogs, Cinacalcet hydrochloride, Medications prescribed for the purpose of phosphorus binding;
15. Screening serum intact PTH >500 pg/mL;
16. Screening corrected calcium out of the normal range;
17. Screening labs that indicate uncontrolled hyperlipidemia in the opinion of the PI;
18. Initiation of chronic maintenance hemodialysis planned within 12 months;
19. Relocation to another area planned within 12 months;
20. Has a known history of immunodeficiency diseases, including a positive HIV test result;
21. Active drug or alcohol dependence or abuse (excluding tobacco use) within the 12 months prior to dosing or evidence of such abuse;
22. .Evidence of active liver disease with AST or ALT levels greater than 3X the upper limit of normal;
23. Has had a major cardiovascular event within 180 days of screening.