Mosaic Vaccine Designer

Purpose: The Mosaic Vaccine Designer will generate candidate vaccine protein cocktails that optimize the coverage, by a small set of mosaic proteins that could be included in a vaccine cocktail, of potential T-cell epitopes in a large diverse set of proteins.

The Mosaic Explanation page provides additional information to get you started. Please read it before using this tool.

Usage: Paste your protein sequences in the box, or upload a file containing sequences. Input sequences do not need to be aligned. When your job is completed, a link to your results will be sent to the e-mail address you provide.
The default maximum runtime is 5 hours. This can be increased up to 100 hours, to get more sophisticated results. Please use the Advanced options. For information on the coverage changes of the mosaic vaccine sequences according to the runtime, see here.

Download stand-alone Mosaic Vaccine Designer

• Mosaic Vaccine Designer source code and documentation

Related Programs

• Epitope Coverage Assessment Tool: Epicover
• Positional Epitope Coverage Assessment Tool: Posicover

Contributors

• Hyejin Yoon - web implementation and perl programming (at lanl.gov, email address 'hyoon'),
• Will Fischer - perl programming (at lanl.gov, email address 'wfischer'),
• Simon Perkins - original algorithm and C programming (at ultraspectral.com, email address 'simon.perkins')

References

• Vaccine design paper (Fischer et al. 2007): Nature abstract or PubMed abstract
• Tool description paper (Thurmond et al. 2008): Bioinformatics abstract or PubMed abstract