RFA on Targeted Mutations to Study
Ethanol-Related Behaviors
The National Institute on Alcohol Abuse and Alcoholism (NIAAA) is
soliciting proposals to use targeted gene disruption and overexpression
techniques in mice to elucidate the roles of specific neuronal proteins in
mediating the effects of ethanol on brain function and behavior. To be
considered responsive to this RFA, applications must propose elucidation
of the relationship between ethanol's effects on a specific aspect of
nervous system function and a specific behavioral effect of ethanol.
NIAAA strongly encourages mouse geneticists with expertise in targeted
mutagenesis techniques to seek collaborations with established alcohol
researchers, in order to bring these powerful approaches to bear on the
elucidation of the mechanisms of alcohol's effects on behavior. Applications
proposing creation of strains of mice bearing new targeted mutations or
overexpressed transgenes, and applications proposing use of previously
existing targeted mutations or overexpressed transgenes will all be
considered responsive to this RFA.
This RFA will use the R01 and R21 grant mechanisms. R01 grants may have a
duration of up to 5 years. While there is no limit on their budget,
investigators requesting more than $500,000 direct costs in any budget year
must obtain permission from NIAAA before submitting such a proposal. R21
grants may have a duration of up to 3 years, and a maximum budget of
$100,000 direct costs per year. NIAAA anticipates making approximately 8
awards. Letters of intent are due on April 5, 2000, and applications are
due on May 5, 2000.
The full text of this RFA can be found at
http://grants.nih.gov/grants/guide/rfa-files/RFA-AA-00-001.html
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