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Sarcoidosis: Research into the Cause of Multi-organ Disease and Clinical Strategies for Therapy (R01)
Release Date: December 12, 2006
Announcement Number: PA-07-136
Application Receipt Date:
February 5, 2007
June 5, 2007
October 5, 2007
February 5, 2008
June 5, 2008
October 5, 2008
February 5, 2009
Funding Contact: May Wong, Ph.D.
Program Area: Neural Environment
Brief Description:
The primary objective of this Funding Opportunity Announcement (FOA) is to stimulate research on the etiology and management
of sarcoidosis, a human disorder of granulomatous inflammation. We encourage research that seeks to identify not only the
cause of sarcoidosis, but seeks related predisposing factors, such as genomic, proteomic, metabolomic, lipidomic or glycomic
factors related to the etiology of sarcoidosis. Investigations might include how sarcoidosis perturbs the innate and acquired
immunity systems; affects multi-organs within the human body; and impacts biobehavioral and psychosocial factors of the individual,
family, and community. The goal is to delineate possible causes and phenotypic host characteristics in susceptible or at
risk people so that preventive strategies can be developed, early diagnosis improved, and better antidotes or therapy devised
to lessen initial disease immunopathology. Interventions that are cost effective and reduce the individual, family, and community
burden of the disease are also encouraged. Also, there is interest for approaches to risk reduction, psychological coping,
and management of complications or side effects of treatment. This program solicits innovative, multidisciplinary basic and
clinical research of sarcoidosis involving the respiratory tract and other frequently involved organs, especially those of
so- called critical involvement (heart, eyes, liver, and neurologic system) with the intent of accelerating progress in the
discovery of the cause of sarcoidosis and its diagnosis, prevention, and treatment. This program also encourages methodologies
and instruments that determine disease burden.
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