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Intercellular Genomics of Subsurface Microbial Colonies

Contents

• Contact Information
• Funding Agency 
• Research Emphasis 
• Scales Examined 
• Biomedical, Biological &  Behavioral Areas
• Modeling Methods & Tools  
• Software Development 

Contact Information

Principal Investigator/Contact
Peter Ortoleva
Indiana University
Phone: (812) 855-2717
Fax: (812) 855-8300
E-mail: ccvt@indiana.edu

Co-PIs and Collaborators
Dr. Dennis Gannon,
Indiana University, Bloomington

Dr. Christof Meile,
University of Georgia, Athens

Grant Number - 

Funding Agency

Department of Energy (DOE-ASCR)

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Research Emphasis

The investigation of feedback mechanisms between microbes and the environment requires a multi-scale approach. This project brings together researchers with modeling expertise at different spatial scales and with complementary scientific fields including physical chemistry, computer science, microbiology and marine sciences.

The project aims to integrate multiple biomic cell models/simulators, porous medium reaction-transport homogenization theory/software, and decades of experience in nonlinear dynamic phenomena in biological, chemical and geological systems.

The software developed will be freely available to the wider environmental and energy sciences research communities. 

Abstract

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Scales Examined 

Time Scales

• Millisecond (ms)
• Second(s)
• Minutes
• Hours
• Days

Biological Scales

• Sub-Cellular
• Cellular
• Multi-Cellular Systems

Length Scales 

• Nanometer and below (nm)
• Micrometer (μm)
• Millimeter (mm)
• Centimeter (cm)
• Ten centimeter

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Biomedical, Biological and Behavioral (BBB) Areas and Percent Focus

25% - bacterial gene regulatory networks, and microbial colonies.

Modeling Methods and Tools (MMT)Areas and Percent Focus

75% - ODEs, PDEs for porous media, microarray analysis, gene ontology, phylogeny, and information theory.  

Software Development