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Module reduction to gain speed (compromising robustness)

Adaptive Multi-Scale Model Simulation, Reduction and Integration for Cardiac Muscle Physiology 

Contents

• Contact Information
• Funding Agency 
• Research Emphasis 
• Disease Focus 
• Scales Examined 
• Biomedical, Biological &  Behavioral Areas
• Modeling Methods & Tools  
• Software Development 

Contact Information

Principal Investigator/Contact
James Bassingthwaighte
University of Washington
Phone: (206) 685-2005
Fax: (206) 685-3300
Email: jbb@bioeng.washington.edu
Project websites: http://www.physiome.org/  and  http://nsr.bioeng.washington.edu

Co-PIs and Collaborators
Howard J. Chizeck
Professor, Electrical Engineering
University of  Washington

Les E. Atlas
Professor, Electrical Engineering
University of  Washington

Hong Qian
Associate Professor, Applied Math
University of  Washington

Grant Number - 0506477

Funding Agency

National Science Foundation (NSF)

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Research Emphasis

The project will develop innovative methods for adaptive multiscale modeling, simulation and model reduction. The result will provide computational strategies and technologies, and their application to cardiac and muscle physiology.

New computational algorithms and methods for spanning multiple modeling scales (regulation of transcription, cellular energetic metabolism, cell-to-cell interactions, and integrated organ contractile function) will be demonstrated. The resulting simulation will provide highly integrated models of cardiac and skeletal muscle systems. In addition to the applicability of this work to physiological problems, the algorithms, source code, manuals and tutorials, all of which will be open source and widely disseminated, will be useful to a wide range of investigators.

Disease Focus

Cardiovascular and skeletal muscle disorders.

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Scales Examined 

Time Scales

• Microsecond (μs)
• Millisecond (ms)
• Second (s)
• Minutes
• Hours

Biological Scales

• Sub-Cellular
• Cellular
• Multi-Cellular Systems
• Tissue
• Organ
• Organ Systems

Length Scales 

• Nanometer and below (nm)
• Micrometer (μm)
• Millimeter (mm)
• Centimeter (cm)
• Ten centimeter
• Meter

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Biomedical, Biological and Behavioral (BBB) Areas and Percent Focus

50% - Biological systems analysis; 40% - Cardiorespiratory modeling; 10%- Simulation software development.

Modeling Methods and Tools (MMT)Areas and Percent Focus

40% - Model development; 30% - Reduced model formulation and optimization; 30% - Automating model substitution.  

Software Development