The Reactome project is a collaboration among Cold Spring Harbor Laboratory,
The European Bioinformatics Institute,
and The Gene Ontology Consortium to develop a curated resource of core pathways and reactions in human biology.
The information in this database is authored by biological researchers with expertise in their fields, maintained by the Reactome editorial staff, and
cross-referenced with the sequence databases at NCBI, Ensembl and
UniProt, the UCSC Genome Browser ,
HapMap, KEGG(Gene and Compound ),
ChEBI, PubMed
and GO.
In addition to curated human events, inferred orthologous events
in 22 non-human species including mouse, rat, chicken, puffer fish, worm, fly, yeast, two plants and E.coli are also available.
A description of Reactome has been published in
Genome Biology and Nucleic Acids Research.
Reactome is a free on-line resource, and Reactome software is open-source. However, please take note of our disclaimer.
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- December 17, 2008 Version 27 Released
New topics released in Version 27 include Hormone biosynthesis
grouping new curated material on peptide hormones with additional descriptions of prostanoid hormone
events, Transmembrane transport of small molecules grouping
new ABC transporter events along with existing transport reactions, Opiod
signaling and Diabetes pathways including Insulin regulation and
IGFBP- mediated events. The pathway topics updated with new curated events include: Signaling by
GPCR (Olfactory receptor
signaling and Receptor-ligand complexes that bind G-proteins),
Integrin cell surface interaction (Integrin alphaIIbbeta3 signaling),
Cell Cycle-G2/M transition (Centrosome maturation),
Gene expression (tRNA Aminoacylation) ,
Metabolism of amino acids (Amino acid transport across the plasma membrane) and Signaling by NGF (calmodulin induced events).
N Le Novere
is our external author and
A Antonellis,
J Bockaert,
L Castagnoli,
L Freedman,
A Merdes,
SJ Shattil,
and
L Vosshall
are our external reviewers in this release.
Protein-protein interaction datasets, statistics and the editorial calendar are available.
The Reactome team thanks users for their comments on the pathway visualization tool.
Click on contact to reach us, on editorial to contribute to Reactome content,
and on subscribe to receive Reactome announcements.
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