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Sponsored by: |
Khon Kaen University |
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Information provided by: | Khon Kaen University |
ClinicalTrials.gov Identifier: | NCT00149253 |
Taken together, studies of the value of pre-emptive analgesia are inconclusive. This randomized, double-blind, dose-ranging, placebo-controlled study was therefore designed to test that a reduction in post-operative morphine consumption can be achieved by a single-dose of etoricoxib before induction of anesthesia.
Condition | Intervention | Phase |
---|---|---|
a Single-Dose of Etoricoxib Post-Operative Morphine Consumption Total Pain Relief Over 8 Hr(TOPAR8) Post Transabdominal Hysterectomy |
Drug: a single-dose of Etoricoxib before induction of anesthesia |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Safety/Efficacy Study |
Official Title: | A Randomized, Double-Blind, Controlled Trial of Etoricoxib as a Pre-Emptive Analgesic for Abdominal Hysterectomy |
Estimated Enrollment: | 50 |
Study Start Date: | December 2004 |
Estimated Study Completion Date: | May 2005 |
Patients undergoing transabdominal hysterectomy were randomized to a group taking a single dose (orally) of etoricoxib 120 mg (n = 18), etoricoxib 180 mg (n = 17) or placebo (n = 15) 2 hours before surgery under the same standardized general anesthesia. At the post-anesthetic care unit, intravenous morphine titration was given before starting self-controlled analgesia (PCA) device. Morphine consumption, pain relief score, sedative score, global evaluation score, and side-effects were recorded at 1, 2, 4, 8 and 24 h post-operatively. The primary end points were morphine consumption within 24-hr post-operatively and total pain relief over 8 h (TOPAR8). Patient global satisfaction was also assessed.
Ages Eligible for Study: | 15 Years to 65 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Thailand, KhonKaen | |
Warporn Chau-in | |
KhonKaen University, KhonKaen, Thailand, 40002 |
Principal Investigator: | waraporn chau-in, Asso Prof. | Department of Anesthesiology, Faculty of Medicine,KhonKaen University,KhonKaen 40002, Thailand |
Study ID Numbers: | acute pain service, Faculty of Medicine,KhonKaenU |
Study First Received: | September 6, 2005 |
Last Updated: | September 6, 2005 |
ClinicalTrials.gov Identifier: | NCT00149253 |
Health Authority: | Thailand: Food and Drug Administration |
Abdominal hysterectomy, Etoricoxib, morphine consumption, pre-emptive analgesia |
Morphine Etoricoxib Pain Pain, Postoperative |
Anti-Inflammatory Agents Molecular Mechanisms of Pharmacological Action Cyclooxygenase Inhibitors Physiological Effects of Drugs Enzyme Inhibitors Pharmacologic Actions Analgesics, Non-Narcotic |
Sensory System Agents Therapeutic Uses Anti-Inflammatory Agents, Non-Steroidal Analgesics Peripheral Nervous System Agents Antirheumatic Agents Central Nervous System Agents |