The Effect of Cycling Off Criteria During Pressure Support Ventilation in Chronic Obstructive Pulmonary Disease (COPD) Patients - Full Text View

Sponsored by:	Policlinico Hospital
Information provided by:	Policlinico Hospital
ClinicalTrials.gov Identifier:	NCT00141440

Purpose

The investigators' aim is to study the effect of cycling off criteria during pressure support ventilation in COPD patients at two levels of PEEP and PSV.

Condition	Intervention
Chronic Obstructive Pulmonary Disease	Procedure: mechanical ventilation

MedlinePlus related topics: COPD (Chronic Obstructive Pulmonary Disease) Gas

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Placebo Control, Single Group Assignment, Efficacy Study
Official Title:	The Effect of Cycling Off Criteria During Pressure Support Ventilation in COPD Patients

Further study details as provided by Policlinico Hospital:

Primary Outcome Measures:

Respiratory mechanics, gas exchange [ Time Frame: 2 minutes ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Comfort of breathing [ Time Frame: 2 minutes ] [ Designated as safety issue: No ]

Enrollment:	13
Study Start Date:	July 2005
Study Completion Date:	March 2007
Primary Completion Date:	March 2007 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Experimental COPD patients	Procedure: mechanical ventilation evaluated the effect of two different cycling off criteria on breathing pattern, respiratory effort, and gas exchange in patients with chronic obstructive pulmonary disease

Detailed Description:

In this study two levels of cycling off criteria at two levels of PEEP and PSV were tested in term of gas exchange, respiratory mechanics, work of breathing and patient comfort.

Eligibility

Ages Eligible for Study:	16 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Stable COPD patients during invasive mechanical ventilation

Exclusion Criteria:

Hemodynamic instability,
Paralysis

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00141440

Locations

Italy
Ospedale Sacco
Milano, Italy, 20100

Sponsors and Collaborators

Policlinico Hospital

Investigators

Principal Investigator:	davide chiumello, md	Policlinico Hospital
Study Chair:	Davide Chiumello, MD	Policlinico

More Information

Responsible Party:	Policlinico Hospital ( Davide Chiumello )
Study ID Numbers:	1073
Study First Received:	August 31, 2005
Last Updated:	September 24, 2008
ClinicalTrials.gov Identifier:	NCT00141440
Health Authority:	Italy: Ministry of Health

Keywords provided by Policlinico Hospital:

gas exchange
pressure support ventilation
respiratory mechanics
COPD patients

Study placed in the following topic categories:

Lung Diseases, Obstructive
Respiratory Tract Diseases
Lung Diseases
Respiration Disorders
Pulmonary Disease, Chronic Obstructive

ClinicalTrials.gov processed this record on January 13, 2009