Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis

This study is currently recruiting participants.

Verified by University Hospital, Angers, September 2005

Sponsored by:	University Hospital, Angers
Information provided by:	University Hospital, Angers
ClinicalTrials.gov Identifier:	NCT00152711

Purpose

This study aims to evaluate the impact of nasal continuous positive airway pressure (nCPAP) treatment on liver enzymes in patients with sleep apnea syndrome and nonalcoholic steatohepatitis. Using a cross over design, the evolution of liver enzymes will be evaluated in 40 patients during a consecutive period of 6 weeks, with and without nCPAP treatment.

Condition	Intervention
Sleep Apnea Syndrome Nonalcoholic Steatohepatitis	Device: nCPAP

MedlinePlus related topics: Sleep Apnea

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Uncontrolled, Crossover Assignment
Official Title:	Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis: A Prospective Cross Over Trial

Further study details as provided by University Hospital, Angers:

Estimated Enrollment:	40
Study Start Date:	September 2004

Eligibility

Ages Eligible for Study:	18 Years to 70 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

18 to 70 years old
Nonalcoholic steatohepatitis proven by liver biopsy
Sleep apnea syndrome proven by polysomnography with an apnea-hypopnea index > 10 events/hour
Informed consent

Exclusion Criteria:

Psychiatric disorder
Other cause of liver disease
Professional driver

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00152711

Contacts

Contact: Frédéric Gagnadoux, MD

33(0)241353695

frgagnadoux@chu-angers.fr

Locations

France
University Hospital Angers	Recruiting
Angers, France
Contact: Frédéric Gagnadoux, MD 33(0)241353695 frgagnadoux@chu-angers.fr

Sponsors and Collaborators

University Hospital, Angers

Investigators

Principal Investigator:

Frédéric Gagnadoux

UH Angers

More Information

Study ID Numbers:	PHRC 03-07
Study First Received:	September 8, 2005
Last Updated:	February 12, 2007
ClinicalTrials.gov Identifier:	NCT00152711
Health Authority:	France: French General Health Administration

Study placed in the following topic categories:

Signs and Symptoms
Liver Diseases
Sleep Apnea Syndromes
Digestive System Diseases
Respiratory Tract Diseases
Apnea

Respiration Disorders
Dyssomnias
Sleep Disorders
Signs and Symptoms, Respiratory
Fatty Liver
Sleep Disorders, Intrinsic

Additional relevant MeSH terms:

Pathologic Processes
Disease
Syndrome
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009