Analysis of Genetic Factors Which May Influence the Course of HIV Infection

This study is currently recruiting participants.

Verified by Hadassah Medical Organization, December 2007

Sponsored by:	Hadassah Medical Organization
Information provided by:	Hadassah Medical Organization
ClinicalTrials.gov Identifier:	NCT00159068

Purpose

Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease. Such factors may be related to metabolism (breakdown) of drugs or to iron handling by the body.

Condition
HIV Infection

MedlinePlus related topics: AIDS

U.S. FDA Resources

Study Type:	Observational
Study Design:	Prospective
Official Title:	Genetic Influences on the Course and Response to Treatment of HIV: Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms

Further study details as provided by Hadassah Medical Organization:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

DNA isolated from peripheral blood.

Estimated Enrollment:	150
Study Start Date:	February 2004
Estimated Study Completion Date:	April 2009

Detailed Description:

Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4. In addition, reports have linked changes in the course of the disease with iron status, with high iron being detrimental. We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters (such as CD4 counts and opportunistic infections).

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patients with HIV attending the HIV clinic at Hadassah colden globes.

Criteria

Inclusion Criteria:

diagnosis of HIV

Exclusion Criteria:

under 18 years of age

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00159068

Contacts

Contact: Deborah Rund, MD	00 972 2 6778712	rund@cc.huji.ac.il
Contact: Arik Tzukert, DMD	00 972 2 6776095	arik@hadassah.org.il

Locations

Israel
Hadassah Medical Organization	Recruiting
Jerusalem, Israel, IL91120
Contact: Arik Tzukert, DMD 00 972 2 6776095 arik@hadassah.org.il
Contact: Hadas l, PhD 00 972 2 6777572 lhadas@hadassah.org.il
Principal Investigator: Deborah Rund, MD

Sponsors and Collaborators

Hadassah Medical Organization

Investigators

Principal Investigator:

Deborah Rund, MD

Hadassah Medical Organization

More Information

Publications:

Tang J, Kaslow RA. The impact of host genetics on HIV infection and disease progression in the era of highly active antiretroviral therapy. AIDS. 2003;17 Suppl 4:S51-60. Review. No abstract available.

Responsible Party:	Hadassah Medical Organization ( Deborah Rund )
Study ID Numbers:	391200-HMO-CTIL
Study First Received:	September 9, 2005
Last Updated:	December 17, 2007
ClinicalTrials.gov Identifier:	NCT00159068
Health Authority:	Israel: Israeli Health Ministry Pharmaceutical Administration

Study placed in the following topic categories:

Virus Diseases
Sexually Transmitted Diseases, Viral
HIV Infections
Sexually Transmitted Diseases

Acquired Immunodeficiency Syndrome
Retroviridae Infections
Immunologic Deficiency Syndromes

Additional relevant MeSH terms:

Communicable Diseases
RNA Virus Infections
Slow Virus Diseases

Immune System Diseases
Lentivirus Infections
Infection

ClinicalTrials.gov processed this record on January 14, 2009