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Sponsored by: |
Hadassah Medical Organization |
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Information provided by: | Hadassah Medical Organization |
ClinicalTrials.gov Identifier: | NCT00159068 |
Patients with HIV an have a variable course of their infection. We are trying to identify factors which worsen or ameliorate the course of the disease. Such factors may be related to metabolism (breakdown) of drugs or to iron handling by the body.
Condition |
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HIV Infection |
Study Type: | Observational |
Study Design: | Prospective |
Official Title: | Genetic Influences on the Course and Response to Treatment of HIV: Contribution of Polymorphisms in Drug Metabolism and Disposition Genes and Haptoglobin Polymorphisms |
DNA isolated from peripheral blood.
Estimated Enrollment: | 150 |
Study Start Date: | February 2004 |
Estimated Study Completion Date: | April 2009 |
Patients with HIV can have a variable course and the disease may be influenced by polymorphisms in drug metabolism and disposition genes such as MDR1 and CYP3A4. In addition, reports have linked changes in the course of the disease with iron status, with high iron being detrimental. We will study polymorphisms in these genes and correlate with clinical course in HIV patients and also with phenotype of drug resistance and disease parameters (such as CD4 counts and opportunistic infections).
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Patients with HIV attending the HIV clinic at Hadassah colden globes.
Inclusion Criteria:
Exclusion Criteria:
Contact: Deborah Rund, MD | 00 972 2 6778712 | rund@cc.huji.ac.il |
Contact: Arik Tzukert, DMD | 00 972 2 6776095 | arik@hadassah.org.il |
Israel | |
Hadassah Medical Organization | Recruiting |
Jerusalem, Israel, IL91120 | |
Contact: Arik Tzukert, DMD 00 972 2 6776095 arik@hadassah.org.il | |
Contact: Hadas l, PhD 00 972 2 6777572 lhadas@hadassah.org.il | |
Principal Investigator: Deborah Rund, MD |
Principal Investigator: | Deborah Rund, MD | Hadassah Medical Organization |
Responsible Party: | Hadassah Medical Organization ( Deborah Rund ) |
Study ID Numbers: | 391200-HMO-CTIL |
Study First Received: | September 9, 2005 |
Last Updated: | December 17, 2007 |
ClinicalTrials.gov Identifier: | NCT00159068 |
Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
Virus Diseases Sexually Transmitted Diseases, Viral HIV Infections Sexually Transmitted Diseases |
Acquired Immunodeficiency Syndrome Retroviridae Infections Immunologic Deficiency Syndromes |
Communicable Diseases RNA Virus Infections Slow Virus Diseases |
Immune System Diseases Lentivirus Infections Infection |