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Sponsors and Collaborators: |
Southwest Oncology Group National Cancer Institute (NCI) Eastern Cooperative Oncology Group |
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Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00003590 |
RATIONALE: Drugs used in chemotherapy such as hydroxyurea use different ways to stop tumor cells from dividing so they stop growing or die.
PURPOSE: This phase II trial is studying how well hydroxyurea works in treating patients with unresectable benign meningioma.
Condition | Intervention | Phase |
---|---|---|
Brain and Central Nervous System Tumors |
Drug: hydroxyurea |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Open Label |
Official Title: | Phase II Study of Hydroxyurea for Unresectable Meningioma |
Estimated Enrollment: | 38 |
Study Start Date: | November 1998 |
OBJECTIVES:
OUTLINE: Patients receive oral hydroxyurea twice daily for 2 years in the absence of disease progression or unacceptable toxicity.
Patients are followed at 3 months, 6 months, and then every 6 months for 3 years.
PROJECTED ACCRUAL: A total of 38 patients will be accrued for this study within 13 months.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
Other:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
Investigator: | Lode J. Swinnen, MD | Sidney Kimmel Comprehensive Cancer Center |
Investigator: | Geoffrey R. Barger, MD | Barbara Ann Karmanos Cancer Institute |
Investigator: | Lode J. Swinnen, MD | Sidney Kimmel Comprehensive Cancer Center |
Study ID Numbers: | CDR0000066659, SWOG-S9811, ECOG-S9811 |
Study First Received: | November 1, 1999 |
Last Updated: | July 23, 2008 |
ClinicalTrials.gov Identifier: | NCT00003590 |
Health Authority: | United States: Federal Government |
recurrent adult brain tumor adult grade I meningioma |
Brain Neoplasms Meningeal Neoplasms Hydroxyurea Meningioma |
Central Nervous System Neoplasms Recurrence Nervous System Neoplasms |
Neoplasms by Histologic Type Antisickling Agents Molecular Mechanisms of Pharmacological Action Antineoplastic Agents Neoplasms, Nerve Tissue Nervous System Diseases Hematologic Agents |
Enzyme Inhibitors Pharmacologic Actions Neoplasms Neoplasms by Site Therapeutic Uses Neoplasms, Vascular Tissue Nucleic Acid Synthesis Inhibitors |