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Sponsored by: |
Pfizer |
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Information provided by: | NIH AIDS Clinical Trials Information Service |
ClinicalTrials.gov Identifier: | NCT00002075 |
To compare the safety and effectiveness of fluconazole and amphotericin B, alone or in combination with flucytosine, as treatment for acute cryptococcal meningitis.
Condition | Intervention |
---|---|
Meningitis, Cryptococcal HIV Infections |
Drug: Flucytosine Drug: Fluconazole Drug: Amphotericin B |
Study Type: | Interventional |
Study Design: | Treatment |
Official Title: | Multicenter Comparison of Fluconazole (UK-49,858) and Amphotericin B as Treatment for Acute Cryptococcal Meningitis |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria
Concurrent Medication:
Allowed:
Concurrent Treatment:
Allowed:
Written informed consent must be obtained for each patient, either from the patient himself or from the patient's legal guardian.
Prior Medication:
Allowed:
Exclusion Criteria
Co-existing Condition:
Patients with the following are excluded:
Concurrent Medication:
Excluded:
Concurrent Treatment:
Excluded:
Patients with the following are excluded:
Prior Medication:
Excluded:
Prior Treatment:
Excluded:
Study ID Numbers: | 012G, 056-159A |
Study First Received: | November 2, 1999 |
Last Updated: | June 23, 2005 |
ClinicalTrials.gov Identifier: | NCT00002075 |
Health Authority: | United States: Food and Drug Administration |
AIDS-Related Opportunistic Infections Meningitis Cryptococcosis Drug Therapy, Combination |
Fluconazole Flucytosine Acquired Immunodeficiency Syndrome Amphotericin B |
Fluconazole Abelcet Amphotericin B Opportunistic Infections Meningitis, Fungal Sexually Transmitted Diseases, Viral Clotrimazole Miconazole Acquired Immunodeficiency Syndrome Tioconazole Central Nervous System Diseases Flucytosine |
Liposomal amphotericin B Immunologic Deficiency Syndromes Meningitis Virus Diseases Mycoses Central Nervous System Infections HIV Infections AIDS-Related Opportunistic Infections Sexually Transmitted Diseases Meningitis, Cryptococcal Cryptococcosis Retroviridae Infections |
Antimetabolites Anti-Infective Agents RNA Virus Infections Antiprotozoal Agents Slow Virus Diseases Molecular Mechanisms of Pharmacological Action Immune System Diseases Nervous System Diseases Infection |
Pharmacologic Actions Anti-Bacterial Agents Antiparasitic Agents Antifungal Agents Therapeutic Uses Antibiotics, Antifungal Lentivirus Infections Central Nervous System Fungal Infections Amebicides |