Pulmonary
Critical Care Medicine Branch (PCCMB)
Joel Moss, MD, PhD, Principal Investigator
The Pulmonary - Critical Care Medicine Branch (P-CCMB) conducts
research related to basic cell and molecular biology, bench-to-bedside
translational research projects, and clinical research on lung disease.
Areas of basic research include:
- Cytokine biology
- Signal transduction pathways (e.g., nitric oxide, G proteins,
cyclic nucleotide phosphodiesterases)
- Vesicular trafficking
- Post-translational modification of proteins (e.g., ADP-ribosylation)
- Mechanisms of bacterial toxin action
P-CCMB translational studies use state-of-the-art techniques (e.g.,
genomics, proteomics) to define the pathogenesis of lung disease
(e.g., asthma, cystic fibrosis, lymphangioleiomyomatosis (LAM),
pulmonary fibrosis, and sarcoidosis). Areas of active clinical investigation
with on-going protocols include:
- identification of clinical, pathological, genetic, and physiological
criteria for the determination of disease severity and progression
in cystic fibrosis, LAM, and pulmonary fibrosis,
- identification of novel therapeutic approaches for the treatment
of lung disease (e.g., asthma and sarcoidosis),
- development of new technologies for the prevention of nosocomial
pneumonia and ventilator-induced injury.
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