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| Dennis L. Murphy, M.D., Senior Investigator |
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Dr. Murphy received his B.S. from Marquette University in 1958 and his Sc.M. and M.D. degrees from the University of Wisconsin in 1963. After a medical internship at the University of Minnesota Hospitals and a Psychiatry Residency at Johns Hopkins University School of Medicine, he joined NIMH as a clinical fellow in 1966. Dr. Murphy became Chief of the Laboratory of Clinical Science in 1983. His laboratory explores the neurobiology of neuropsychiatric disorders using molecular, neurochemical and genetic techniques.
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Research Interests:
The Laboratory of Clinical Science (LCS) explores the neurobiology of neuropsychiatric disorders using molecular, neurochemical and genetic techniques. Its present focus links studies of transgenic mice with studies of clinical brain disorders such as OCD and depression using gene-environment interaction models. The serotonin neurotransmitter system and several of its key molecules, including the serotonin transporter (SERT) (Figure 1) and serotonin receptors and enzymes are the primary targets of LCS research. The development of the SERT knockout mouse in the LCS provided a new living tool to discover what the serotonin system does, as SERT and serotonin receptors are the target molecules for the largest numbers of neuropsychiatric drugs used in the world. The 40 plus neurochemical, behavioral and other phenotypic changes discovered in the serotonin knockout mouse are helping to guide the LCS and other laboratories in investigations of the multiple variants in the human SERT gene and other serotonin-related brain genes (Figure 2).
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Selected Recent Publications:
Ren-Patterson RF, Cochran LW, Holmes A, Sherrill S, Huang SJ, Tolliver T, Lesch K-P (2005) Loss of brain-derived neurotrophic factor gene allele exacerbates brain monoamine deficiences and increases stress abnormalities of serotonin transporter knockout mice, J Neurosci Res.
Full Text/Abstract
Murphy DL, Lerner A, Rudnick G, Lesch K-P (2005) Serotonin transporter: gene, genetic disorders, and pharmacogenetics, Mol Interv 4, 109-23.
Full Text/Abstract
Ren-Patterson RF, Kim D-K, Zheng X, Sherrill S, Huang S-J, Tolliver T, Murphy DL (2005) Serotonergic-like progenitor cells porpagated from neural stem cells in vitro: survival with SERT protein expression following implantation into brains of mice lacking SERT, Faseb J.
Full Text/Abstract
Li Q, Holmes A, Ma L, Van de Kar LD, Garcia F, Murphy DL (2004) Medical hypothalamic 5-hydroxytryptamine (5HT)1A receptors regulate neuroendocrine responses to stress and exploratory locomotor activity application of recombinant adenovirus containing 5-HT1A sequences., J Neurosci 24, 10868-77.
Full Text/Abstract
Kilic F, Murphy DL, Rudnick G (2003) A human serotonin transporter mutation causes constitutive activation of transport activity, Mol Pharmacol 64, 440-46.
Full Text/Abstract
Murphy DL, Uhl GR, Holmes A, Ren-Patterson R, Hall FS, Sora I, Detera-Wadleigh S, Lesch K-P (2003) Experimental gene interaction studies with SERT mutant mice as models for human polygenic and epistatic traits and disorders. , Genes Brain Behav 2, 350-64.
Full Text/Abstract
Ozaki N, Goldman D, Kaye WH, Plotnicov K, Greenberg BD, Lappalainen J, Rudnick G, Murphy DL (2003) Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype, Molecular Psychiatry 8, 933-936.
Full Text/Abstract
All Selected Publications
Contact Information:
Dr. Dennis L. Murphy
Clinical Neuropharmacology Section
Laboratory of Clinical Science, NIMH
Building 10, Room 3D41
10 Center Drive, MSC 1264
Bethesda, MD 20892-1264
Telephone: (301) 496-3421 (office),
(301) 402-0188 (fax)
Email: DennisMurphy@mail.nih.gov
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