Table of Contents

November 2002
Volume 15, Issue 11
Pages 1331-1487
For Selected Articles:

PERSPECTIVE

Acetaldehyde in Mainstream Tobacco Smoke:  Formation and Occurrence in Smoke and Bioavailability in the Smoker

Jeffrey I. Seeman,*† Michael Dixon,*‡ and Hans-Jürgen Haussmann*§
pp 1331–1350
Publication Date (Web): November 18, 2002 (Perspective)
DOI: 10.1021/tx020069f
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COMMUNICATIONS

Metabolic Profiling of the Effects of d-Galactosamine in Liver Spheroids Using 1H NMR and MAS-NMR Spectroscopy

Mary E. Bollard,*† Jinsheng Xu,‡ Wendy Purcell,‡ Julian L. Griffin,† Christopher Quirk,§ Elaine Holmes,† and Jeremy K. Nicholson†
pp 1351–1359
Publication Date (Web): October 19, 2002 (Communication)
DOI: 10.1021/tx025571e
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ARTICLES

Biological Monitoring of 2,4,5-Trichlorophenol (I):  Preparation of Antibodies and Development of an Immunoassay Using Theoretical Models

Mikaela Nichkova, Roger Galve, and M.-Pilar Marco*
pp 1360–1370
Publication Date (Web): October 10, 2002 (Article)
DOI: 10.1021/tx025555h
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Biological Monitoring of 2,4,5-Trichlorophenol (II):  Evaluation of an Enzyme-Linked Immunosorbent Assay for the Analysis of Water, Urine, and Serum Samples

Mikaela Nichkova, Roger Galve, and M.-Pilar Marco*
pp 1371–1379
Publication Date (Web): October 10, 2002 (Article)
DOI: 10.1021/tx025556+
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Analytical Reproducibility in 1H NMR-Based Metabonomic Urinalysis

Hector C. Keun,*† Timothy M. D. Ebbels,† Henrik Antti,† Mary E. Bollard,† Olaf Beckonert,† Götz Schlotterbeck,‡ Hans Senn,‡ Urs Niederhauser,‡ Elaine Holmes,† John C. Lindon,† and Jeremy K. Nicholson†
pp 1380–1386
Publication Date (Web): October 17, 2002 (Article)
DOI: 10.1021/tx0255774
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Mass Spectral Characterization of Dichloroacetic Acid-Modified Human Glutathione Transferase Zeta

Wayne B. Anderson,† Daniel C. Liebler,‡ Philip G. Board,§ and M. W. Anders*†
pp 1387–1397
Publication Date (Web): September 27, 2002 (Article)
DOI: 10.1021/tx025553x
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Relative Toxicities of DNA Cross-Links and Monoadducts:  New Insights from Studies of Decarbamoyl Mitomycin C and Mitomycin C

Yolanda Palom,†‡ Gopinatha Suresh Kumar,†§ Li-Qian Tang, Manuel M. Paz,†# Steven M. Musser, Sara Rockwell, and Maria Tomasz*†
pp 1398–1406
Publication Date (Web): October 08, 2002 (Article)
DOI: 10.1021/tx020044g
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Substrate Routes to the Buried Active Site May Vary among Cytochromes P450:  Mutagenesis of the F−G Region in P450 2B1†

Emily E. Scott,* You Qun He, and James R. Halpert
pp 1407–1413
Publication Date (Web): October 09, 2002 (Article)
DOI: 10.1021/tx020057u
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Microsomal Oxidation of Tribromoethylene and Reactions of Tribromoethylene Oxide

Tadao Yoshioka, Joel A. Krauser, and F. Peter Guengerich*
pp 1414–1420
Publication Date (Web): October 10, 2002 (Article)
DOI: 10.1021/tx020047t
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Species Differences in the in Vitro Metabolic Activation of the Hepatotoxic Pyrrolizidine Alkaloid Clivorine

Ge Lin,*† Yan-Yan Cui,† Xiao-Quan Liu,†‡ and Zhen-Tao Wang§
pp 1421–1428
Publication Date (Web): October 10, 2002 (Article)
DOI: 10.1021/tx0255370
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Molecular Modeling of Four Stereoisomers of the Major B[a]PDE Adduct (at N2-dG) in Five Cases Where the Structure Is Known from NMR Studies:  Molecular Modeling Is Consistent with NMR Results

Chiu Hong Lee, Sushil Chandani, and Edward L. Loechler*
pp 1429–1444
Publication Date (Web): October 12, 2002 (Article)
DOI: 10.1021/tx0200257
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Covalent Modification of Amino Acid Nucleophiles by the Lipid Peroxidation Products 4-Hydroxy-2-nonenal and 4-Oxo-2-nonenal†

Jonathan A. Doorn and Dennis R. Petersen*
pp 1445–1450
Publication Date (Web): October 05, 2002 (Article)
DOI: 10.1021/tx025590o
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Antioxidant Balance and Free Radical Generation in Vitamin E-Deficient Mice after Dermal Exposure to Cumene Hydroperoxide

A. A. Shvedova,*† E. R. Kisin,† A. R. Murray,‡ C. Kommineni,† V. Castranova,† R. P. Mason,§ M. B. Kadiiska,§ and M. R. Gunther‡
pp 1451–1459
Publication Date (Web): October 18, 2002 (Article)
DOI: 10.1021/tx0200313
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Synthesis of Oligonucleotides and Thermal Stability of Duplexes Containing the β-C-Nucleoside Analogue of Fapy·dG

Michael O. Delaney† and Marc M. Greenberg*‡
pp 1460–1465
Publication Date (Web): October 17, 2002 (Article)
DOI: 10.1021/tx025588x
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Biliary Excretion of [(GS)2AsSe]- after Intravenous Injection of Rabbits with Arsenite and Selenate

Jürgen Gailer,* Graham N. George,† Ingrid J. Pickering,† Roger C. Prince,‡ Husam S. Younis,§ and J. J. Winzerling
pp 1466–1471
Publication Date (Web): October 24, 2002 (Article)
DOI: 10.1021/tx025538s
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Metabolic Response of Normal and Malignant Tissue to Acute and Chronic Methionine Stress in Athymic Mice Bearing Human Glial Tumor Xenografts

Demetrius M. Kokkinakis,* Jacquellyn B. Wick, and Qing Xian Zhou
pp 1472–1479
Publication Date (Web): October 24, 2002 (Article)
DOI: 10.1021/tx020033n
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Enantioselective Covalent Binding of 2-Phenylpropionic Acid to Protein in Vitro in Rat Hepatocytes†

Chunze Li, Leslie Z. Benet,* and Mark P. Grillo‡
pp 1480–1487
Publication Date (Web): October 31, 2002 (Article)
DOI: 10.1021/tx025600l
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