On the cover: What factors determine responsiveness to TGFβ and limit the signals so that they reach only the appropriate tissues with the correct intensity? The assembly of the Smad complex is critical for TGFβ signaling. In this issue of Cell, Dupont et al. (pp. 123–135) describe Smad4 monoubiquitination and deubiquitination as a way by which cells shape their responsiveness to TGFβ. This study may provide insight into understanding diseases associated with unrestrained TGFβ signaling. On the cover, how TGFβ signal transduction is shaped by Smad4 ubiquitination is depicted as a canyon that has been shaped over time by the elements. Photo credit: Harry Hu, used with permission under license from 123RF.
SnapShots present up-to-date tables of nomenclature and glossaries, full signaling pathways, and schematic diagrams of cellular processes. Click here for a full list of SnapShots. Centriole Biogenesis
|
Job Seekers: View the latest Jobs in Life Science on the all-new Cell Career Network!
Employers/Recruiters: Post your vacancies and learn more about our various recruitment advertising solutions. Click here for more information.
Postdoctoral positions are available in the Department of Genetics and Tumor Cell Biology to work in different aspects of mammalian organogenesis using available mouse models. Highly motivated individuals who recently obtained a PhD or MD degree and have a strong background in molecular and developmental biology are encouraged to apply. Click here for more information.
Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis
Grzegorz Sumara, Ivan Formentini, Stephan Collins, Izabela Sumara, Renata Windak, Bernd Bodenmiller, Reshma Ramracheya, Dorothée Caille, Huiping Jiang, Kenneth A. Platt, Paolo Meda, Rudolf Aebersold, Patrik Rorsman, and Romeo Ricci
The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection In tuberculosis, aggregates of immune cells known as granulomas have long been thought to act to constrain mycobacterial infection by serving as a cellular barrier to “wall off” the bacteria. Using intravital imaging to study the early events of infection in a zebrafish model for tuberculosis, Davis and Ramakrishnan now provide evidence indicating that the triggering of the innate immune response and the recruitment of macrophages associated with granuloma formation may actually facilitate the expansion of the infection. |
In this PaperClip, Dr. Fabiola Rivas speaks with Dr. Lalita Ramakrishnan about her group's study showing that granuloma formation promotes mycobacterial expansion and dissemination during the early stages of tuberculosis infection.
|
In this Review, Changchun Xiao and Klaus Rajewsky discuss emerging themes in the regulation of the mammalian immune system by microRNAs.
MicroRNA Control in the Immune System: Basic Principles |
In this PaperClip, Dr. Angela Andersen speaks with Dr. Tim Nilsen about his group's study which identifies new splice site silencers and provides insight into how alternative splice sites are chosen.
|
You can listen directly by clicking on the player above. For a complete list of Cell PaperClips, click here
In our latest podcast, we hear from Dr. Nathaniel Heintz about "TRAP," a new technique reported in Cell for looking at gene expression in the brain. Then we learn about a study in Current Biology from Dr. Robert Fleischer regarding the curious classification of the Hawaiian honeyeater. And we will also hear from Dr. Alan Beggs about his study in the American Journal of Human Genetics presenting a large-scale screen for mutations involved in Diamond-Blackfan anemia.
And stay tuned for a round-up of some of the exciting research advances recently published in Cell and the Cell Press family of journals. |
You can listen directly by clicking on the player above. To learn about other ways to listen to the podcast, click here.