News and Views

Research by Larry Hawk and colleagues suggests that a longer duration of varenicline treatment prior to smoking cessation improves abstinence outcomes. Read the article here. Read press coverage here.

Suicidal thoughts and behavior in clinical trials: a statistical assessment. Read the press release here!

TOP TEN MOST VIEWED PAPERS

The top ten charts the articles that have been downloaded most often over the previous 30 days, in HTML and PDF format, from the Clinical Pharmacology & Therapeutics website recently. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.

December 2012

1. The Use of Induced Pluripotent Stem Cells in Drug Development

   H Inoue & S Yamanaka

   doi:10.1038/clpt.2011.38

   Abstract | Full Text | PDF

2. The effect of fluoxetine on the pharmacokinetics and psychomotor responses of diazepam

   Louis Lemberger, Howard Rowe, Janet C Bosomworth, Jennifer B Tenbarge & Richard F Bergstrom

   doi:10.1038/clpt.1988.52

   Abstract | Full Text | PDF

3. Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion–Transporting Polypeptides

   M J Dolton, B D Roufogalis & A J McLachlan

   doi:10.1038/clpt.2012.159

   Abstract | Full Text | PDF

4. The Genetic and Epigenetic Basis of Type 2 Diabetes and Obesity

   A W Drong, C M Lindgren & M I McCarthy

   doi:10.1038/clpt.2012.149

   Abstract | Full Text | PDF

5. New Avenues for Anticoagulation in Atrial Fibrillation

   S Mantha, K Cabral & J Ansell

   doi:10.1038/clpt.2012.197

   Abstract | Full Text | PDF

6. Clinical Applications for microRNAs in Cancer

   S P Nana-Sinkam & C M Croce

   doi:10.1038/clpt.2012.192

   Abstract | Full Text | PDF

7. Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

   R M Naylor, D J Baker & J M van Deursen

   doi:10.1038/clpt.2012.193

   Abstract | Full Text | PDF

8. Clinical Pharmacogenomics: Opportunities and Challenges at Point of Care

   S A Scott

   doi:10.1038/clpt.2012.196

   Abstract | Full Text | PDF

9. Developing New Drug Treatments in the Era of Network Medicine

   E K Silverman & J Loscalzo

   doi:10.1038/clpt.2012.207

   Abstract | Full Text | PDF

10. Epigenomics and Interindividual Differences in Drug Response

    M Ivanov, M Kacevska & M Ingelman-Sundberg

    doi:10.1038/clpt.2012.152

    Abstract | Full Text | PDF