Insulin Receptor Structure, Function, and Action
The Insulin Receptor/Structure/Function/Action Program encompasses studies of the Insulin Receptor in health and disease. Specific areas of support include;
- molecular analysis of ligand binding to receptor;
- activation of the tyrosine kinase;
- the insulin receptor as a relay platform for signals involved in insulin action;
- the Insulin Receptor Signaling proteins ((IRS)-1,2,3,4) and other proteins containing Src Homology Domains that participate in signaling downstream of the insulin receptor; and
- glucose transport, including kinetics, regulation, and structure of transport proteins in muscle, liver, heart, gut, pancreas, and kidney, and regulation of glucose transporter (GLUT) storage, translocation and gene expression by hormones, diet, and metabolic state (including fasting, obesity).
- kinetic and structural studies of transporters and/or membrane channels of nutrients other than glucose. These may include amino acids, ions and metals.
For more information, contact Dr. Olivier Blondel, Director, Endocrine Systems Biology Program
Resources for Researchers
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Funding Opportunities
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NIDDK Staff
- Dr. Kristin Abraham, Cell Signaling and Diabetes Centers Program Director
- Dr. Terry Bishop, Hematology Research Programs Director
- Dr. Olivier Blondel, Director, Endocrine Systems Biology Program
- Dr. Arthur Castle, Director, Metabolomics and Informatics Programs
- Dr. Edward Doo, Director of the Liver Diseases Program
- Dr. Judith Fradkin, Director, Division of Diabetes, Endocrinology, and Metabolic Diseases
- Dr. Carol Haft, Senior Advisor for Cell Biology, Associate Director for Grants Administration
- Dr. James Hyde, Senior Advisor, Research Training and Career Development Programs
- Dr. Teresa Jones, Diabetes Complications Program Director
- Dr. Maren Laughlin, Senior Advisor for Integrative Metabolism
- Dr. Saul Malozowski, Senior Advisor for Endocrine Physiology
- Dr. Ronald Margolis, Senior Advisor, Molecular Endocrinology
- Dr. Michael May, Director, Gastrointestinal Neuroendocrinology Program
- Dr. Catherine McKeon, Senior Advisor for Genetic Research in Diabetes, Endocrinology and Metabolic Diseases
- Dr. Sheryl Sato , Director, Neurobiology of Obesity and Developmental Biology
- Dr. Salvatore Sechi, Proteomic Program Director
- Dr. Jose Serrano, Director of the Liver and Biliary Program; Director of the Pancreas Program
- Dr. Myrlene Staten, Senior Advisor, Diabetes Research Translation
- Dr. Daniel Wright, Hematology Research Programs Director
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Page last updated: November 25, 2008