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ibuprofen A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand name: | ![](https://webarchive.library.unt.edu/web/20090115050126im_/http://www.cancer.gov/images/spacer.gif) | Motrin | | ![](https://webarchive.library.unt.edu/web/20090115050126im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/web/20090115050126im_/http://www.cancer.gov/images/spacer.gif) | - benzeneacetic acid, alpha-methyl-4-(2-methylpropyl)-
- p-isobutylhydratropic acid
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