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bizelesin A synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/web/20090115065714im_/http://www.cancer.gov/images/spacer.gif) | U-77779 | | ![](https://webarchive.library.unt.edu/web/20090115065714im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/web/20090115065714im_/http://www.cancer.gov/images/spacer.gif) | benzo(1,2-b:4,3-b')dipyrrol-4-ol,6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(S-(R*,R*)) | | ![](https://webarchive.library.unt.edu/web/20090115065714im_/http://www.cancer.gov/images/spacer.gif) |
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