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therapeutic tumor infiltrating lymphocytes A preparation of cells, consisting of autologous tumor infiltrating lymphocytes, that are manipulated in vitro and, upon administration in vivo, re-infiltrate the tumor to initiate tumor cell lysis. In vitro, therapeutic tumor-infiltrating lymphocytes (TILs) are isolated from tumor tissue and cultured with lymphokines such as interleukin-2; the therapeutic TILs are then infused into the patient, where, after re-infiltration of the tumor, they may induce lysis of tumor cells and tumor regression. The use of therapeutic TILs is considered a form of adoptive immunotherapy. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/web/20090115032647im_/http://www.cancer.gov/images/spacer.gif) | tumor infiltrating lymphocytes | | ![](https://webarchive.library.unt.edu/web/20090115032647im_/http://www.cancer.gov/images/spacer.gif) |
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