General Information
Cancer arising in the extrahepatic bile duct is an uncommon disease, curable by
surgery in fewer than 10% of all cases.[1] Prognosis depends in part on the
tumor’s anatomic location, which affects its resectability. Total resection is
possible in 25% to 30% of lesions that originate in the distal bile duct, a
resectability rate that is clearly better than for lesions that occur in more
proximal sites.[2]
Bile duct cancer may occur more frequently in patients with
a history of primary sclerosing cholangitis, chronic ulcerative colitis,
choledochal cysts, or infections with the fluke, Clonorchis sinensis.[3] The
most common symptoms caused by bile duct cancer are jaundice, pain, fever, and
pruritus.
In most patients, the tumor cannot be completely removed by surgery
and is incurable. Palliative resections or other palliative measures such as
radiation therapy (e.g., brachytherapy or external-beam radiation therapy) or
stenting procedures may maintain adequate biliary drainage and allow for
improved survival. Many bile duct cancers are multifocal. Perineural invasion
has a negative impact on survival.[4]
References
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Henson DE, Albores-Saavedra J, Corle D: Carcinoma of the extrahepatic bile ducts. Histologic types, stage of disease, grade, and survival rates. Cancer 70 (6): 1498-501, 1992.
[PUBMED Abstract]
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Stain SC, Baer HU, Dennison AR, et al.: Current management of hilar cholangiocarcinoma. Surg Gynecol Obstet 175 (6): 579-88, 1992.
[PUBMED Abstract]
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de Groen PC, Gores GJ, LaRusso NF, et al.: Biliary tract cancers. N Engl J Med 341 (18): 1368-78, 1999.
[PUBMED Abstract]
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Bhuiya MR, Nimura Y, Kamiya J, et al.: Clinicopathologic studies on perineural invasion of bile duct carcinoma. Ann Surg 215 (4): 344-9, 1992.
[PUBMED Abstract]
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