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metformin hydrochloride The hydrochloride salt of the biguanide metformin with antihyperglycemic activity. Metformin decreases hepatic gluconeogenesis and intestinal absorption of glucose. This agent also increases the number and/or affinity of insulin receptors on muscle and adipose cells, increasing the sensitivity to insulin at receptor and post-receptor binding sites and increasing glucose uptake peripherally. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name: | | Glucophage | | | Chemical structure names: | | - 1,1-dimethylbiguanide hydrochloride
- N,N-dimethylimidodicarbonimidic diamide monohydrochloride
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