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becatecarin A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin. Becatecarin intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/web/20090115070636im_/http://www.cancer.gov/images/spacer.gif) | DEAE-rebeccamycin rebeccamycin analogue rebeccamycin analogue, tartrate salt | | ![](https://webarchive.library.unt.edu/web/20090115070636im_/http://www.cancer.gov/images/spacer.gif) | Code names: | ![](https://webarchive.library.unt.edu/web/20090115070636im_/http://www.cancer.gov/images/spacer.gif) | BMS-181176 BMY-27557-14 XL119 | | ![](https://webarchive.library.unt.edu/web/20090115070636im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/web/20090115070636im_/http://www.cancer.gov/images/spacer.gif) | 5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)- | | ![](https://webarchive.library.unt.edu/web/20090115070636im_/http://www.cancer.gov/images/spacer.gif) |
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