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chloroquinoxaline sulfonamide A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity. Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis. This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/web/20090115060847im_/http://www.cancer.gov/images/spacer.gif) | chlorosulfaquinoxaline chlorsulfaquinoxaline | | ![](https://webarchive.library.unt.edu/web/20090115060847im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/web/20090115060847im_/http://www.cancer.gov/images/spacer.gif) | CQS | | ![](https://webarchive.library.unt.edu/web/20090115060847im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/web/20090115060847im_/http://www.cancer.gov/images/spacer.gif) | benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)- | | ![](https://webarchive.library.unt.edu/web/20090115060847im_/http://www.cancer.gov/images/spacer.gif) |
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