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Must Read
F1000 Factor 6.0

New Finding
Structural elucidation of a PRP8 core domain from the heart of the spliceosome.
Ritchie DB, Schellenberg MJ, …, Stuart DT, Macmillan AM
Nat Struct Mol Biol 2008 Nov 15(11):1199-205 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Charles Query
Evaluated 16 Jan 2009

Must Read
F1000 Factor 6.0

New Finding
GTPase cycle of dynamin is coupled to membrane squeeze and release, leading to spontaneous fission.
Bashkirov PV, Akimov SA, …, Zimmerberg J, Frolov VA
Cell 2008 Dec 26 135(7):1276-86 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elizabeth Smythe
Evaluated 16 Jan 2009

Recommended
F1000 Factor 3.0

New Finding
Induction of c-Fos and DeltaFosB immunoreactivity in rat brain by Vagal nerve stimulation.
Cunningham JT, Mifflin SW, Gould GG, Frazer A
Neuropsychopharmacology 2008 Jul 33(8):1884-95 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Linda Rinaman
Evaluated 16 Jan 2009

Recommended
F1000 Factor 3.0

New Finding
SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells.
Bell RD, Deane R, …, Miano JM, Zlokovic BV
Nat Cell Biol 2008 Dec 21 [abstract on PubMed] [related articles] [full text]
Selected by | Kenneth Gross with Aimee Stablewski
Evaluated 16 Jan 2009

Must Read
F1000 Factor 6.0

New Finding
Real-time visualization of dynamin-catalyzed membrane fission and vesicle release.
Pucadyil TJ, Schmid SL
Cell 2008 Dec 26 135(7):1263-75 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Elizabeth Smythe
Evaluated 16 Jan 2009

Must Read
F1000 Factor 6.0

Hypothesis
Novel Drug Target
Chemical and biological approaches synergize to ameliorate protein-folding diseases.
Mu TW, Ong DS, …, Segatori L, Kelly JW
Cell 2008 Sep 5 134(5):769-81 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Douglas Cyr with Meredith Rosser
Evaluated 16 Jan 2009


Must Read
F1000 Factor 6.0

Hypothesis
The importance of the variance around the mean effect size of ecological processes.
Benedetti-Cecchi L
Ecology 2003 84:2335-46 [full text]
Selected by | John Sabo with Elizabeth Hagen and Jim Elser
Evaluated 16 Jan 2009

Recommended
F1000 Factor 3.0

Hypothesis
New Finding
Epoxyeicosatrienoic Acid Activates BK Channels in the Cortical Collecting Duct.
Sun P, Liu W, …, Satlin LM, Wang WH
J Am Soc Nephrol 2008 Dec 10 [abstract on PubMed] [related articles] [full text]
Selected by | John Imig
Evaluated 16 Jan 2009

Must Read
F1000 Factor 6.0

New Finding
Direct inhibition of GSK3beta by the phosphorylated cytoplasmic domain of LRP6 in Wnt/beta-catenin signaling.
Piao S, Lee SH, …, Weis WI, Ha NC
PLoS ONE 2008 3(12):e4046 [abstract on PubMed] [related articles] [FREE full text]
Selected by | Mariann Bienz
Evaluated 16 Jan 2009

Recommended
F1000 Factor 3.0

New Finding
Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation.
Sriskantharajah S, Belich MP, …, Seddon B, Ley SC
Nat Immunol 2009 Jan 10(1):38-47 [abstract on PubMed] [related articles] [full text] [order article]
Selected by | Steve Ward
Evaluated 16 Jan 2009


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