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karenitecin A synthetic silicon-containing agent related to camptothecin with antineoplastic properties. Karenitecin stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis. Because it is lipophilic, karenitecin exhibits enhanced tissue penetration and bio-availability compared to water-soluble camptothecins. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/web/20090114233720im_/http://www.cancer.gov/images/spacer.gif) | BNP1350 | | ![](https://webarchive.library.unt.edu/web/20090114233720im_/http://www.cancer.gov/images/spacer.gif) |
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