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Update on the Management of Gonorrhea in Adults in the United States.
Clin Infect Dis 2007;44(Suppl 3):S84-S101.
Newman LM, Moran JS, Workowski KA.
Abstract
Gonorrhea, the second most commonly reported notifiable disease, is an important
cause of cervicitis, urethritis, and pelvic inflammatory disease. The selection
of appropriate therapy for gonorrhea (i.e., safe, highly effective, single
dose, and affordable) is complicated by the ability of Neisseria gonorrhoeae
to develop resistance to antimicrobial therapies. This article reviews the
key questions and data that informed the 2006 gonorrhea treatment recommendations
of the Centers for Disease Control and Prevention. Key areas addressed include
the criteria used to select effective treatment for gonorrhea, the level of
antimicrobial resistance at which changing treatment regimens is recommended,
the epidemiology of resistance, and the use of quinolones, cephalosporins,
and other classes of antimicrobials for the treatment of uncomplicated gonorrhea.