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Sponsored by: |
AstraZeneca |
---|---|
Information provided by: | AstraZeneca |
ClinicalTrials.gov Identifier: | NCT00686504 |
The study is carried out in order to determine the relationship between AZD2066 exposure and mGluR5 receptor occupancy in the brain and to demonstrate that AZD2066 can displace [11C]AZ12713580 from mGluR5 binding-sites in the Central Nervous System
Condition | Intervention | Phase |
---|---|---|
Healthy |
Drug: AZD2066 Drug: radioligand [11C] AZ12713580 |
Phase I |
Study Type: | Interventional |
Study Design: | Basic Science, Non-Randomized, Open Label, Single Group Assignment, Pharmacokinetics Study |
Official Title: | An Open Label, Non-Randomized Positron Emission Tomography (PET) Study With [11C]AZ12713580 to Determine Central mGluR5 Receptor Occupancy of AZD2066 After Oral Administration to Healthy Subjects |
Estimated Enrollment: | 6 |
Study Start Date: | April 2008 |
Study Completion Date: | July 2008 |
Primary Completion Date: | June 2008 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 20 Years to 45 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Sweden | |
Research Site | |
STOCKHOLM, Sweden |
Principal Investigator: | Bo Fransson | Astrazeneca Clinical Pharmacology Unit, Stockholm, Sweden |
Study Director: | Sophia Bengtsson | AstraZeneca R&D, Study Delivery, Clinical Development, Södertälje, Sweden |
Responsible Party: | AstraZeneca R&D Södertälje, Sweden ( Rolf Karlsten, MD, PhD, Medical Science Director, Emerging Analgesia ) |
Study ID Numbers: | D0475C00013, EudractCT 2008-000064-17 |
Study First Received: | May 27, 2008 |
Last Updated: | August 29, 2008 |
ClinicalTrials.gov Identifier: | NCT00686504 |
Health Authority: | Sweden: Medical Products Agency; Sweden: Regional Ethical Review Board |
Pain PET Phase 1 Analgesia |
Positron Emission Tomography mGlu5 receptor Dose finding Analgesia/Pain |
Signs and Symptoms Pain Healthy |