Inclusion Criteria:

Inclusion:

1. Pathologically documented pancreatic adenocarcinoma deemed unresectable due to local involvement of vessels or organs
2. No prior chemotherapy or Radiation therapy
3. ECOG Performance Status 0-1
4. Clinically measurable or evaluable disease
5. Life expectancy of at least 12 weeks
6. Granulocyte count > 1500/uL
7. Platelet count > 100,000/uL
8. Hemoglobin > 9 g/dL
9. Adequate renal function with creatinine < 1.5 times ULN
10. Adequate biliary function with bilirubin < 3.0 g/dL (including patients who have been bypassed or treated with percutaneous drainage)
11. SGPT (ALT) < 2.5
12. Age > 18 years

Exclusion Criteria:

1. Known allergy to one of the study drugs
2. Women of child bearing potential who are unwilling or unable to use an acceptable method to avoid pregnancy and women who are pregnant and breastfeeding
3. Prior malignancy
4. CNS metastases
5. Peripheral neuropathy > grade2
6. Serious concomitant systemic disorder or illness
7. Active infection or uncontrolled infection
8. Presence of metastatic disease
9. Inadequate organ function as discussed above
10. Use of any investigational agent within a month of treatment