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Sponsored by: |
UMC Utrecht |
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Information provided by: | UMC Utrecht |
ClinicalTrials.gov Identifier: | NCT00463164 |
This study aims to investigate the role of fronto-striatal circuits and cognitive control in the perseverative and inflexible behavior that is a defining feature of autism. We hypothesize that deficits in the development of fronto-striatal circuitry may underlie cognitive inflexibility in autism. Specifically, we hypothesize that repetitive, inflexible behavior arises as (1) fronto-striatal systems are capable of learning patterns present in the environment (as in implicit learning paradigms), but are unable to adapt behavior to changing circumstances, related to either (2) decreased ability of basal ganglia to detect violations of expectancy, (3) decreased ability of prefrontal cortex to respond to detected violations, or (4) decreased connectivity of the circuits. We are conducting three functional Magnetic Resonance Imaging (fMRI) studies to address these hypotheses.
Condition |
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Autism |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Case Control, Prospective Study |
Official Title: | Functional MRI of Cognitive Control in Autism |
Ages Eligible for Study: | 6 Years to 12 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Inclusion criteria for subjects with autism
Inclusion criteria for controls
Exclusion Criteria:
Contact: Sarah Durston, Ph.D. | +31 30 250 8161 | S.Durston@umcutrecht.nl |
Netherlands | |
Dept. of Child and Adolescent Psychiatry, UMC Utrecht | |
Utrecht, Netherlands, 3584CX |
Principal Investigator: | Sarah Durston, Ph.D. | Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht |
Study Chair: | Herman van Engeland, M.D. Ph.D. | Rudolf Magnust Institute of Neuroscience, UMC Utrecht |
Study ID Numbers: | 06-179 |
Study First Received: | April 19, 2007 |
Last Updated: | April 19, 2007 |
ClinicalTrials.gov Identifier: | NCT00463164 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
functional MRI |
Developmental Disabilities Child Development Disorders, Pervasive Mental Disorders Autistic Disorder Mental Disorders Diagnosed in Childhood |