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Sponsors and Collaborators: |
Children's Hospital of Philadelphia University of Pennsylvania Woman and Children’s Hospital of Buffalo, NY Children's Mercy Hospital Kansas City St. Louis Children's Hospital Children's Hospital & Research Center Oakland Alta Bates Summit Medical Center Long Island Jewish Medical Center |
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Information provided by: | Children's Hospital of Philadelphia |
ClinicalTrials.gov Identifier: | NCT00208039 |
A research study that will evaluate if giving surfactant medication to premature babies weighing < 1250 gm at birth during the second and third weeks of life will help their lungs. We are enrolling those premature babies who continue to require the breathing tube and the mechanical ventilator at days 7-10 of life.
Condition | Intervention |
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Respiratory Distress Syndrome Bronchopulmonary Dysplasia |
Drug: Infasurf |
Study Type: | Interventional |
Study Design: | Treatment, Non-Randomized, Open Label, Historical Control, Single Group Assignment, Safety/Efficacy Study |
Official Title: | Pilot Trial of Surfactant Booster Prophylaxis For Ventilated Preterm Neonates Less Than or Equal to 1250 gm Birthweight Ver 4.0 |
Enrollment: | 89 |
Study Start Date: | September 2004 |
Study Completion Date: | November 2007 |
Pulmonary surfactant is required for normal lung function. Data from a previous study suggest that as many as 75% of chronically ventilated extremely low birthweight premature infants have at least one episode of surfactant dysfunction beyond the first week of life, as measured in vitro, associated with a low surfactant protein B content. Furthermore, episodes of surfactant dysfunction are significantly associated with clinically significant respiratory decompensations. We hypothesize that booster doses of surfactant given during the second and third week of life to extremely low birth weight premature infants requiring persistent intubation and mechanical ventilation will improve their respiratory status during the first 28 days of life. We propose to enroll premature infants < 1250 gm birthweight, between days 7 and 10 of life who are intubated, and mechanically ventilated. Infants requiring persistent intubation and mechanical ventilation for respiratory support at 7-10 days of life will receive a total of 3 doses of Infasurf surfactant, 3 days apart, at the standard dose of 3 ml/kg. Primary outcome is the change in area under the respiratory severity score curve between days 7 and 28 of life. Total sample size is 88 infants, study duration is 36 months, and recruitment of study patients will occur at The Hospital of the University of Pennsylvania, in Philadelphia PA, Women and Children's Hospital in Buffalo, St. Louis Children's Hospital in St. Louis MO, Mercy Children's Hospital in Kansas City, Oakland Children's and Alta Bates Medical Center in Berkeley, CA and Long Island Jewish Medical Center, NY.
Ages Eligible for Study: | up to 10 Days |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Note: Prior surfactant therapy at birth is neither an inclusion nor exclusion criterion.
Principal Investigator: | Michael Posencheg, MD | University of Pennsylvania/Children's Hospital of Philadelphia |
Principal Investigator: | Roberta A Ballard, MD | University of California, San Francisco Medical Center |
Study ID Numbers: | 2004-9-3983 |
Study First Received: | September 13, 2005 |
Last Updated: | November 19, 2007 |
ClinicalTrials.gov Identifier: | NCT00208039 |
Health Authority: | United States: Food and Drug Administration |
Prematurity Lung Disease Hyaline Membrane Surfactant |
Bronchopulmonary dysplasia Birth Weight Bronchopulmonary Dysplasia Respiratory Tract Diseases Lung Diseases Respiration Disorders |
Respiratory Distress Syndrome, Adult Infant, Newborn, Diseases Acute respiratory distress syndrome Infant, Premature, Diseases Calfactant |
Respiratory System Agents Pathologic Processes Disease Therapeutic Uses |
Syndrome Pharmacologic Actions Pulmonary Surfactants |