Inclusion Criteria:

• Subjects aged 18-85 years who have given written informed consent.
• A body mass index between 18-35 calculated using Quetelets index-weight (kg)/height² (m).
• Subjects with, in the opinion of the Investigator, clinically acceptable results for the laboratory tests and ECG as specified in the trial protocol (see Protocol Section 6.4.2). All laboratory tests must be performed within 28 days of the first trial dose administration.
• Female patients of child bearing potential who are using a highly effective method(s) of contraception and agree to do so from at least the screening visit until one month after administration of the final study dose. For the purposes of the protocol, highly effective method(s) of contraception will be defined as consistently and correctly used implants, injectables, combined oral contraceptives, sexual abstinence or a vasectomised partner

Exclusion Criteria:

• Subjects who on direct questioning and physical examination have history or evidence of hypertrophic or keloid scarring.
• Subjects with tattoos, birthmarks, moles or previous scars within 3cm of the area to be investigated during the trial.
• Afro-Caribbean subjects are excluded because of the increased susceptibility to hypertrophic and keloid scarring.
• Subjects who have had surgery in the area to be investigated within one year of the first dosing day.
• Subjects with a skin disorder that is chronic or currently active and which the Investigator considers will adversely affect the healing of the acute wounds or involves the areas to be examined in this trial.

• Subjects with any clinically significant medical condition or history of any condition that would impair wound healing including :

  • Subjects with renal impairment (creatinine clearance (CLcr) of 80/ml/min or less)
  • Significant hepatic impairment (LFTs >3 times upper limit of normal).
  • Congestive heart failure with a classification of >2 according to the NYHA Classification (see appendix 5).
  • A history of myocardial infarction, ischaemic heart disease (or presenting with symptoms or signs compatible with ischaemic heart disease), coronary vasospasm or peripheral vascular disease.
  • Subjects, with significant cerebrovascular disease including a history of stroke, transient ischaemic attacks or haemorrhage.
  • Malignancy (unless treated and disease-free for 5 years).
  • Autoimmune disease (including active rheumatoid arthritis), immunosuppression (oral corticosteroids) or chemotherapy within the last 12 months.
  • Uncontrolled hypertension SBP > 180 mmHg, DBP > 95mmHg.
  • Diabetes (except diet controlled)
  • Significant respiratory disease.
• Subjects with a history of clinically relevant allergy, hypersensitivity, angioedema, or anaphylaxis.
• Subjects with a progressive neurological condition including Parkinson's disease, Alzheimer's disease and uncontrolled epilepsy.
• Subjects with a known history of chronic viral infection (Hepatitis, HIV) or ongoing active infection.
• Subjects with bleeding disorders including haemophilia, purpura or thrombocytopenia or receiving anticoagulants (e.g. warfarin, coumadin).
• Subjects who have taken any investigational product in the twelve months prior to first trial dose administration.
• Subjects undergoing investigations or changes in management for an existing medical condition.
• Subjects with a history of substance abuse or dependency ( a history of recreational use of cannabis is acceptable assuming a negative urine test for cannabis at screen. Subjects who have had a history of alcohol abuse but have been dependency free for 12 months will still be eligible).
• Subjects with any condition or serious illness which, in the opinion of the Investigator, would interfere with participation in the study.
• Subjects with an ongoing psychiatric condition requiring treatment or psychosis (including depression with psychosis, bipolar disease and schizophrenia).
• Female subjects who are breast feeding, or intending to become pregnant or breast feed during the study period (subjects must be using adequate contraception and have a negative pregnancy test at screening - see Inclusion).
• Female subjects who have had any change in their oral contraceptive medication (if applicable) in the 2 months prior to screening, or anticipate any change during study participation.