Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome - Full Text View

Sponsored by:	University Hospital, Clermont-Ferrand
Information provided by:	University Hospital, Clermont-Ferrand
ClinicalTrials.gov Identifier:	NCT00664300

Purpose

Gilles de la Tourette's syndrome is a childhood onset inherited neuropsychiatric disorder characterised by the presence of both multiple motor tics and one or more vocal tics (noises), with psychiatric and/or behaviour disorders (such as obsessive compulsive behaviour…).

This disease is associated with an dopamine system imbalance which could be responsible of a specific trouble in the recognition in some facial expression. This has been already shown in Gilles de la Tourette patients with obsessive compulsive behaviour.

We hypothesise that patients with Gilles de la Tourette's syndrome present a dysfunction of voluntary and automatic treatment of emotional information.

The main purpose of this study is to show if patients with Gilles de la Tourette's syndrome present a lack of specific facial expression recognition of emotion and determinate more precisely if this alteration involves the cortical way (high frequency way) or the under cortical way (low frequency way).

Condition	Intervention
Gilles de la Tourette's Syndrome	Behavioral: Facial expression recognition of emotion

Genetics Home Reference related topics: familial encephalopathy with neuroserpin inclusion bodies familial paroxysmal nonkinesigenic dyskinesia Tourette syndrome

MedlinePlus related topics: Tourette Syndrome

U.S. FDA Resources

Study Type:	Observational
Official Title:	Facial Expression Recognition of Emotion and Categorization of Emotional Words in Gilles de la Tourette's Syndrome

Further study details as provided by University Hospital, Clermont-Ferrand:

Primary Outcome Measures:

Facial expression recognition test [ Time Frame: % of exact responses ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:

Lexical decision test [ Time Frame: The time to respond ] [ Designated as safety issue: Yes ]

Estimated Enrollment:	60
Study Start Date:	September 2007
Estimated Study Completion Date:	May 2009
Estimated Primary Completion Date:	October 2008 (Final data collection date for primary outcome measure)

Groups/Cohorts	Assigned Interventions
2 One group with Gilles de la Tourette's Syndrome One group with healthy paired volunteers	Behavioral: Facial expression recognition of emotion Facial expression recognition test Lexical decision test

Detailed Description:

20 patients with Gilles de la Tourette's syndrome compared to 20 healthy paired volunteers.

Study progress (patients):

Inclusion visit :

Psychiatric evaluation Psychological evaluation

Ophthalmic visit

Protocol :

Facial expression recognition test Lexical decision test

Study progress (healthy volunteers):

Psychiatric evaluation Ophthalmic visit Facial expression recognition test Lexical decision test

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Probability Sample

Study Population

30 patients with Gilles de la Tourette's Syndrome and 30 healthy paired volunteers (control group)

Criteria

Inclusion Criteria:

Age : >18 years
Patient with a Gilles de la Tourette 's syndrome such as defined in the DSMIV
Stability of treatment >1 month
Mini Mental State > 26
Affiliation to social security
Agreement of patients

Exclusion Criteria:

Patients with cognitive disorders, dementia, mental retardation…
Patients with serious neurological pathologies
Patients with a vision contrast altered.
Patients who do not understand the words associated with an emotion
Pregnant women
Person who participate to an other study

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00664300

Contacts

Contact: Patrick Lacarin

04.73.751.195

placarin@chu-clermontferrand.fr

Locations

France
CHU	Recruiting
Clermont-Ferrand, France, 63003

Sponsors and Collaborators

University Hospital, Clermont-Ferrand

Investigators

Principal Investigator:

Isabelle Jalenques, PUPH

University Hospital, Clermont-Ferrand

More Information

Responsible Party:	CHU Clermont-Ferrand ( Pr Jalenques )
Study ID Numbers:	CHU-0032, RBHP 2007 Jalenques
Study First Received:	April 21, 2008
Last Updated:	April 21, 2008
ClinicalTrials.gov Identifier:	NCT00664300
Health Authority:	France: Ministry of Health

Keywords provided by University Hospital, Clermont-Ferrand:

Gilles de la Tourette's syndrome
Facial expression recognition of emotion
Frequency levels
Automatic and voluntary information treatment
Patient with Gilles de la Tourette's syndrome

Study placed in the following topic categories:

Ganglion Cysts
Facies
Basal Ganglia Diseases
Central Nervous System Diseases
Tourette Syndrome
Tic Disorders
Brain Diseases
Neurodegenerative Diseases

Tics
Heredodegenerative Disorders, Nervous System
Genetic Diseases, Inborn
Movement Disorders
Mental Disorders
Mental Disorders Diagnosed in Childhood
Gilles de la Tourette's syndrome

Additional relevant MeSH terms:

Pathologic Processes
Disease
Syndrome
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009