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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institute of Neurological Disorders and Stroke (NINDS) |
ClinicalTrials.gov Identifier: | NCT00032695 |
The purpose of this study is to determine whether methionine, an amino acid present in low doses in the normal diet, can improve myelopathy or stop its progression.
Condition | Intervention | Phase |
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Myelopathy AIDS-Myelopathy AIDS Vacuolar Myelopathy |
Drug: methionine |
Phase III |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control |
Estimated Enrollment: | 56 |
Myelopathy is usually a late complication of AIDS, and until recently its symptoms were rarely recognized, masked by the general state of disability or the presence of other neurological complications. With prolonged survival and improved quality of life of HIV-infected patients, myelopathy is increasingly becoming a common source of disability. The cause of AIDS-myelopathy is unknown, but it is probably an indirect effect of the long-term presence of the HIV virus in the nervous system rather than the result of a direct infection. The purpose of this study is to determine whether methionine, an amino acid present in low doses in the normal diet, can improve myelopathy or stop its progression.
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Between 18 and 80 years of age
Study ID Numbers: | R01NS35745 |
Study First Received: | March 28, 2002 |
Last Updated: | May 12, 2006 |
ClinicalTrials.gov Identifier: | NCT00032695 |
Health Authority: | United States: Federal Government |
myelopathy AIDS-myelopathy AIDS vacuolar myelopathy methionine |
Virus Diseases Sexually Transmitted Diseases, Viral Spinal Cord Diseases HIV Infections Sexually Transmitted Diseases |
Acquired Immunodeficiency Syndrome Central Nervous System Diseases Retroviridae Infections Immunologic Deficiency Syndromes |
RNA Virus Infections Slow Virus Diseases Immune System Diseases Nervous System Diseases Lentivirus Infections |