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Sponsored by: |
Changhai Hospital |
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Information provided by: | Changhai Hospital |
ClinicalTrials.gov Identifier: | NCT00819871 |
NFKB1 -94ins/del polymorphism has been reported to be associated with reduced promoter activity of NFKB1 and several clinical diseases, but the clinical results cannot always be replicated. Besides, mutate allele is associated with alleviated inflammation in ulcerative colitis and some tumors, but aggravated inflammation in ARDS. The clinical value of this polymorphism remains controversial. This study was performed to investigate the association of NFKB1 -94ins/delATTG polymorphism with lung and/or kidney injury after cardiac surgery with CPB.
Condition |
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Single Nucleotide Polymorphism Acute Lung Injury Kidney Injury |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Association of NFKB1 -94 Polymorphism With Lung and/or Kidney Injury After Cardiac Surgery With Cardiopulmonary Bypass |
3ml blood before surgery, after surgery and 24h after surgery respectively
Enrollment: | 105 |
Study Start Date: | May 2008 |
Study Completion Date: | December 2008 |
Primary Completion Date: | October 2008 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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PLI
patients with postoperative lung injury
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without PLI
patients without postoperative lung injury
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PLI/PKI
patients with at least one organ injury of lung or kidney after surgery
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without PLI/PKI
patients without lung or kidney injury after surgery
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Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Chinese Han patients undergoing elective cardiac surgery with CPB
Inclusion Criteria:
Exclusion Criteria:
Responsible Party: | Department of Anesthesiology and Intensive Care Unit, Changhai Hospital |
Study ID Numbers: | PCSP-NFKB1 |
Study First Received: | January 8, 2009 |
Last Updated: | January 8, 2009 |
ClinicalTrials.gov Identifier: | NCT00819871 |
Health Authority: | China: Ethics Committee |
Respiratory Tract Diseases Lung Diseases Respiration Disorders Respiratory Distress Syndrome, Adult Acute respiratory distress syndrome |