Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
Assistance Publique - Hôpitaux de Paris |
---|---|
Information provided by: | Assistance Publique - Hôpitaux de Paris |
ClinicalTrials.gov Identifier: | NCT00577525 |
The primary purpose of the study is to evaluate the association of a latent infection of lymphoid cells during the first manifestation of steroid sensitive nephrite syndrome. The thirty nine units of general pediatrics and pediatric nephrite covering the parisian area will participate to the study. We speculate that hybridization of the genome, or a part of the genome, of a virus in lymphoid cells is responsible specific changes of genes expression, leading to the development of the disease.
Condition |
---|
Nephrosis, Lipoid |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Viral Infection of Lymphoid Cells Occuring at the First Manifestation of Idiopathic Nephrotic Syndrome |
whole blood, serum, red cells and DNA
Estimated Enrollment: | 360 |
Study Start Date: | December 2007 |
Estimated Study Completion Date: | November 2011 |
Estimated Primary Completion Date: | March 2011 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
---|
1
Case : Patients with steroid sensitive nephrotic syndrome
|
2
Controls (matched for age and sexe with the first group)
|
An additional blood volume will be sampled in patients and controls during a scheduled biological check-up for the initial disease and viral genome of EBV, CMV, HHV6, HHV7 as well as adenovirus will be searched for using PCR reaction in total blood DNA extract. The frequency of a latent hybridization of virus genome within human genome will be compared between patients with steroid sensitive nephrotic syndrome and controls matched for age and sex. Secondary studies will include a comparison of steroid dependency in nephrotic patients according to the occurence of a latent viral hybridization, the epidemiology of idiopathic nephrotic syndrome in the Parisian area and a pharmacogenetic analysis of steroid sensitivity and dependency. If necessary, the chromosomal localization of viral hybridization will be studied with fluorescence in situ hybridization using specific probes.
Ages Eligible for Study: | 1 Year to 16 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
From the thirty nine units of general pediatrics and pediatric nephrology covering the Parisian area
Inclusion Criteria:
Exclusion Criteria:
Contact: Georges Deschênes, MD PhD | 33 1 40 03 24 55 | georges.deschenes@rdb.aphp.fr |
France | |
Hospital Robert Debre | Recruiting |
Paris, France, 75945 | |
Principal Investigator: Georges Deschênes, MD PhD |
Principal Investigator: | Georges DESCHENES, PHD | Assistance Publique - Hôpitaux de Paris |
Responsible Party: | Department of clinical research and development ( Christophe AUCAN ) |
Study ID Numbers: | P070126, AOM 07018 |
Study First Received: | December 19, 2007 |
Last Updated: | December 8, 2008 |
ClinicalTrials.gov Identifier: | NCT00577525 |
Health Authority: | France: Ministry of Health |
LATENT VIRAL INFECTION GENOME HYBRIDIZATION HERPES VIRUS ADENOVIRUS |
Virus Diseases Nephrosis Nephrosis, Lipoid Urologic Diseases |
Adenoviridae Infections Kidney Diseases Nephrotic Syndrome |
Infection |